HCPLive Network

Antipsychotics Induce Insulin Resistance Without Weight Gain

THURSDAY, July 18 (HealthDay News) -- Atypical antipsychotic drugs induce insulin resistance even in the absence of weight gain and mechanisms regulating eating behavior, according to a study published online July 8 in Diabetes.

To examine whether atypical antipsychotic drugs have detrimental metabolic effects independent of weight gain or psychiatric disease, Karen L. Teff, PhD, from the Monell Chemical Senses Center in Philadelphia, and colleagues treated healthy people as inpatients in a controlled setting with olanzapine, aripiprazole, or placebo for nine days (10 people per group) while maintaining activity levels.

The researchers found that, compared with placebo, olanzapine (which has been strongly associated with weight gain) treatment was associated with significant increases in postprandial insulin, glucagon-like peptide 1, and glucagon, as well as insulin resistance. In contrast, aripiprazole (which has been considered metabolically sparing) had no effect on postprandial hormones but also induced insulin resistance. The changes occurred without weight gain, increase in food intake and hunger, or psychiatric disease.

"Our findings suggest that interventions inhibiting weight gain in atypical antipsychotic-treated patients may be only partially effective in preventing metabolic disease since the drugs are exerting direct effects on tissue function," Teff and colleagues conclude.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2013 HealthDay. All rights reserved.

Further Reading
Researchers from the University of Missouri recently published study results indicating testosterone may play an integral role within colon cancer tumor formation.
In the early postoperative period, ondansetron is associated with increased requirements for tramadol consumption, according to a review and meta-analysis published online Dec. 10 in Anaesthesia.
The number of invasive diagnostic procedures, including amniocentesis, is down significantly after the introduction of noninvasive prenatal testing, according to a study published in the January issue of the Journal of Clinical Ultrasound.
More Reading