HCPLive Network

Antipsychotics Induce Insulin Resistance Without Weight Gain

THURSDAY, July 18 (HealthDay News) -- Atypical antipsychotic drugs induce insulin resistance even in the absence of weight gain and mechanisms regulating eating behavior, according to a study published online July 8 in Diabetes.

To examine whether atypical antipsychotic drugs have detrimental metabolic effects independent of weight gain or psychiatric disease, Karen L. Teff, PhD, from the Monell Chemical Senses Center in Philadelphia, and colleagues treated healthy people as inpatients in a controlled setting with olanzapine, aripiprazole, or placebo for nine days (10 people per group) while maintaining activity levels.

The researchers found that, compared with placebo, olanzapine (which has been strongly associated with weight gain) treatment was associated with significant increases in postprandial insulin, glucagon-like peptide 1, and glucagon, as well as insulin resistance. In contrast, aripiprazole (which has been considered metabolically sparing) had no effect on postprandial hormones but also induced insulin resistance. The changes occurred without weight gain, increase in food intake and hunger, or psychiatric disease.

"Our findings suggest that interventions inhibiting weight gain in atypical antipsychotic-treated patients may be only partially effective in preventing metabolic disease since the drugs are exerting direct effects on tissue function," Teff and colleagues conclude.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2013 HealthDay. All rights reserved.
Further Reading
As healthcare organizations look to cut costs while increasing patient safety and satisfaction, the focus is all landing on how to make the employee happy.
As the nation tries to cut its health-care costs critics of reform have worried that some patients who need expensive though risky procedures like coronary artery bypass graft surgery might not get them. But a new Harvard School of Public Health study could allay those fears.
With more people than ever using cell phones, tablets, and other personal technological devices, dermatologists have voiced concerns over the increase in cases of nickel allergies. Nickel, one of the most prevalent allergens in the United States, can be found within most handheld electronic devices and jewelry.
Although hemodialysis is a commonly used treatment for kidney failure, a recent study has shown it may not be as beneficial for people who develop a sudden case of the condition.
Healthcare workers in poor nations often do not have enough protective gear to keep them safe from being infected with blood-borne viruses such as Ebola and HIV, according to a study published online Aug. 8 in Tropical Medicine & International Health.
Para-aortic radiation correlates with increased diabetes mellitus risk for Hodgkin's lymphoma survivors, according to a study published online Aug. 25 in the Journal of Clinical Oncology.
For patients with stiff person syndrome, autologous hematopoietic stem cell transplantation can induce prolonged clinical remission, according to a case report published online Aug. 25 in JAMA Neurology.
More Reading