HCPLive Network

Atherosclerosis Noted in Pediatric HIV Patients

 
THURSDAY, Dec. 6 (HealthDay News) -- Children and adolescents with HIV have a significantly increased intima-media thickness (IMT), according to a study presented at the European Society of Cardiology's EUROECHO & other Imaging Modalities 2012, held from Dec. 5 to 8 in Athens, Greece.

Talia Sainz Costa, M.D., from the University General Hospital Gregorio Maranon in Madrid, Spain, and colleagues used echocardiography to evaluate carotid IMT in 150 HIV-infected pediatric and adolescent patients and 150 controls. Anthropometric and lipid measures were recorded.

The researchers found that IMT was significantly thicker in HIV patients compared with control subjects (0.434 versus 0.424; P = 0.018). HIV was independently associated with thicker IMT (odds ratio, 2.68) after adjustment for age, sex, body mass index, and smoking status. In subgroup analysis of 34 patients with HIV and 11 controls for whom immune activation markers were determined, frequencies of activated T CD4+ cells were significantly higher among HIV infected patients. Compared to patients with undetectable viral loads or control subjects, treated and viremic patients had the highest frequency of CD4+ and CD8+ activation and senescence.

"HIV research is investigating ways to control the inflammation and immune activation with agents such as probiotics, aspirin, and corticoids. In the meantime clinicians need to focus on ensuring their young patients with HIV take the antiretroviral treatment, take lipid lowering drugs when necessary, and adopt healthier lifestyles," Sainz Costa said in a statement.
 

Press Release
More Information

 
Copyright © 2012 HealthDay. All rights reserved.
 
 

Further Reading
Cardiovascular disease is a long-term complication of type 1 diabetes mellitus, and more attention toward management of its associated risk factors and modifiers is urged in a scientific statement published in the October issue of Diabetes Care.
Adolescent depression is a serious mental illness that results in negative health consequences and frequently recurs later in life. Although the prevalence rate of depression is around 20 percent among African American and European-American adolescents, the associated risks and utilization rates vary greatly.
Recent pharmaceutical studies show work in helping patients with high blood pressure and elevated cholesterol levels.
Advances in treatment could provide much needed help for patients with obesity, diabetes, and hypertension
Targets of workplace bullying can offer chaos, report, or quest narratives about their experiences, and coworker response plays a role in narrative development, according to a study published online Sept. 25 in Management Communication Quarterly.
While in-office visits may still be best, virtual analysis may be a valuable option in atopic dermatitis care, according to a new study published online Oct. 22 in JAMA Dermatology.
The US health care system ranks last compared to other industrialized nations when it comes to affordability and patient access, according to a new survey published in the Oct. 23 issue of the New England Journal of Medicine.
More Reading