HCPLive Network

Calorie-Restricted Weight Loss Restores Ghrelin Sensitivity

 
MONDAY, Jan. 21 (HealthDay News) -- In a mouse model, calorie-restricted weight loss reverses the high-fat diet-induced ghrelin resistance that may contribute to rebound weight gain, according to research published online Jan. 10 in Endocrinology.

Noting that high-fat diet feeding causes ghrelin resistance in neuropeptide Y (NPY)/agouti-related protein (AgRP) neurons, Dana I. Briggs, Ph.D., of Monash University in Clayton, Australia, and colleagues used a diet-induced obese (DIO) mouse model to study the role of ghrelin resistance in diet-induced weight loss and rebound weight gain. DIO mice were allocated to receive chow ad libitum or chow diet with 40 percent calorie restriction until they reached the weight of age-matched lean controls.

The researchers found that body weight, glucose tolerance, and plasma insulin all normalized with both dietary interventions. Calorie restriction-induced weight loss correlated with increased plasma ghrelin, restoration of ghrelin sensitivity, and increases in total NPY/AgRP mRNA expression.

"We show that calorie-restricted weight loss after diet-induced obesity restores the ability of ghrelin to induce food intake, indicating a reversal of diet-induced obesity ghrelin resistance with diet-induced weight loss," the authors write. "We suggest long-term diet-induced obesity changes the body weight setpoint, and as the body interprets calorie-restricted weight loss as negative energy balance, ghrelin fights to defend this higher body weight. This represents a novel target to restrict rebound weight gain in humans."
 

Abstract
Full Text (subscription or payment may be required)


Copyright © 2013 HealthDay. All rights reserved.
 
 

Further Reading
For low-income adults with uncontrolled asthma, home visitation by community health workers is associated with improvements in asthma control and quality of life, according to a study published online Nov. 24 in JAMA Internal Medicine.
With the advent of ongoing audits for medical necessity and accurate coding, whose documentation is being scrutinized to ensure that the medical services being provided are reasonable and necessary? The answer: physicians.
In more than 50 years of medical practice, I only have one memory of my physician-dad being involved in a medical malpractice case. Perhaps there were others, but nothing that I can recall. The one was bad enough.
More Reading