HCPLive Network

Epidural Steroid Shot Has Adverse Effect on Bone Density

 
MONDAY, Dec. 3 (HealthDay News) -- For postmenopausal women, treatment of the pain associated with radiculopathy with epidural steroid injection (ESI) has an adverse effect on bone mineral density (BMD), according to a study published in the Dec. 1 issue of Spine.

Ahmad Al-Shoha, M.B.B.S., of the Summa Health System in Akron, Ohio, and colleagues conducted a prospective, observational study involving 28 postmenopausal women experiencing pain associated with radiculopathy who elected to have an L4-L5 ESI. BMD was measured at baseline (pre-injection) and at three and six months post-injection.

Compared with baseline, at six months the researchers observed a significant decrease of 0.018 g/cm² in hip BMD, compared with a 0.003 g/cm² decline in an age-matched control population. There was a significant 2.33 U/L increase in bone-specific alkaline phosphatase, a marker of bone turnover, from three to six months, while the increase in serum C-telopeptide of collagen I was not significant.

"Our findings show that epidural administration of corticosteroids has a deleterious effect on bone, which should be considered when contemplating treatment options for radiculopathy," the authors write. "The resulting decrease in BMD, while slight, suggests that ESIs should be used with caution in those at a risk for fracture."

One or more authors disclosed financial ties to a commercial entity related directly or indirectly to the study.
 

Abstract
Full Text (subscription or payment may be required)

 
Copyright © 2012 HealthDay. All rights reserved.
 
 

Further Reading
In remarks delivered at the American Academy of Family Physicians 2014 Assembly, HHS Secretary Sylvia Mathews Burwell spoke about the ongoing response to the Ebola outbreak, improving health care delivery, the Affordable Care Act, and the Transforming Clinical Practice Initiative.
Seniors who wear their dentures when they sleep are at increased risk for pneumonia, according to a study published online Oct. 7 in the Journal of Dental Research.
New York and New Jersey health officials announced today that all health care workers returning from caring for patients in Ebola hot zones in West Africa will have to go into quarantine for 21 days. The new policy is stricter than the current one recommended by the US Centers for Disease Control and Prevention that calls for health monitoring for 21 days. It was that policy that allowed Craig Spencer, MD to be out and about a day before he was diagnosed with Ebola Thursday and rushed to city-run Bellevue Hospital Center in Manhattan.
A pattern of sleep disturbance is a risk factor for depression and suicide and also increases the risk of cancer, infection, hypertension, weight gain, heart disease, diabetes, inflammation, osteoporosis, chronic pain, and arrhythmias. It can also have a significant negative impact on cognition and creativity.
There is little variation in risk-adjusted hospital readmission rates after colorectal surgery, according to a study published online Oct. 22 in JAMA Surgery.
Cardiovascular disease is a long-term complication of type 1 diabetes mellitus, and more attention toward management of its associated risk factors and modifiers is urged in a scientific statement published in the October issue of Diabetes Care.
For patients with lumbosacral disc herniation, neurophysiological tests together with neuroimaging and clinical examination allow for accurate preoperative assessment of injury, according to a study published in the Oct. 1 issue of Spine.
More Reading