HCPLive Network

Even Correctly Administered NSAIDs Can Cause Acute Kidney Injury in Kids

 
TUESDAY, Jan. 29 (HealthDay News) -- Nonsteroidal anti-inflammatory drug (NSAID)-associated acute kidney injury (AKI) accounts for almost 3 percent of pediatric AKI, according to a study published online Jan. 28 in The Journal of Pediatrics.

Jason M. Misurac, M.D., from Indiana University in Indianapolis, and colleagues retrospectively reviewed the charts of 1,015 children with a diagnosis of AKI to characterize NSAID-linked AKI. A diagnosis explaining AKI or comorbid clinical conditions predisposing to AKI development negated a classification of NSAID-associated AKI.

The researchers found that 21 children had clinical, laboratory, and radiographic studies suggesting NSAID-associated acute tubular necrosis and six had findings suggesting NSAID-associated acute interstitial nephritis, representing 2.7 percent of the total cohort with AKI. The median age for children with NSAID-associated AKI was 14.7 years and four patients were younger than 5 years. Of the 20 children for whom dosing data were available, 75 percent received NSAIDs within recommended dosing limits. Dialysis, intensive care unit admission, and longer length of stays were significantly more likely in children younger than 5 years of age.

"NSAID-associated AKI accounted for 2.7 percent of AKI in this pediatric population," the authors write. "AKI typically occurred after the administration of correctly dosed NSAIDs. Young children with NSAID-associated AKI may have increased disease severity."
 

Abstract
Full Text (subscription or payment may be required)


Copyright © 2013 HealthDay. All rights reserved.
 
 
 
Further Reading
Roughly half of all family medicine and internal medicine positions remained unfilled last year, leaving large gaps in primary care access for many communities.
The nation’s youth, and its smoke-free air need federal protection from vapors from e-cigarettes, according to a set of recommendations released Aug. 25 by the American and Heart Association.
Recommendations have been provided for the use of fluoride in caries prevention in the primary care setting and published online Aug. 25 as a clinical report in Pediatrics.
Although confusional arousals are common in the general population, they may be associated with other factors, such as medication consumption, sleep disorders, and mental disorders, according to research published in the Aug. 26 issue of Neurology.
Efforts to combat the ongoing Ebola outbreak in West Africa have gone global as Japan recently announced efforts to provide medical assistance to the cause.
Low birth weight is associated with increased risk of type 2 diabetes in black women, independent of body mass index, according to research published in the September issue of Diabetes Care.
Hospital and health care providers should follow the U.S. Centers for Disease Control and Prevention's recommendations for care of patients with Ebola, according to an ideas and opinions piece published online Aug. 21 in the Annals of Internal Medicine.
More Reading