Noting that the American Academy of Pediatrics' guidelines recommend aggressive diagnosis, treatment, and investigation of possible pediatric urinary tract infection in children with fever who are younger than 2 years, David H. Newman, M.D., of the Mount Sinai School of Medicine in New York City, and colleagues reviewed the literature to examine the utility and efficacy of this early identification and treatment. They focused specifically on the utility of antibiotics for reducing delayed renal complications and the utility of timely diagnosis and treatment in prevention of renal scarring.
The researchers found that, although two studies linked aggressive and early identification of urinary tract infection with prevention of long-term renal complications, a more substantive body of evidence did not find evidence for this link. In addition, renal scarring was found to be relatively common, but there was no evidence suggesting that scarring has long-term sequelae.
Abstract
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