HCPLive Network

Fetal NSAID Exposure Not Tied to Persistent Pulmonary Hypertension

 
MONDAY, Dec. 3 (HealthDay News) -- There appears to be no association between persistent pulmonary hypertension of the newborn (PPHN) and gestational exposure to nonsteroidal anti-inflammatory drugs (NSAIDs), including ibuprofen, according to a study published online Dec. 3 in Pediatrics.

To examine the correlation between antenatal exposure to NSAIDs and the risk for PPHN, Linda J. Van Marter, M.D., M.P.H., from Boston Children's Hospital, and colleagues interviewed 377 women whose infants had PPHN, along with 836 control mother/infant pairs matched by hospital and delivery date. Questions included information about prescribed and over-the-counter medications used during pregnancy.

The researchers found that 8.8 percent of infants with PPHN were exposed to any NSAID during the third trimester, compared with 9.6 percent of controls (odds ratio, 0.8; 95 percent confidence interval, 0.5 to 1.3). The odds of PPHN were elevated for infants whose mothers consumed aspirin during the third trimester, but the lower 95 percent confidence interval included the null. Neither ibuprofen use during the third trimester nor non-aspirin NSAIDs at any time during pregnancy was associated with an increased risk of PPHN. There was also no association found between third-trimester acetaminophen exposure and the occurrence of PPHN.

"This large multicenter epidemiologic study of PPHN risk revealed no evidence to support the hypothesis that maternal consumption during pregnancy of NSAIDs overall or ibuprofen in particular is associated with PPHN risk," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.
 

Abstract
Full Text (subscription or payment may be required)

 
Copyright © 2012 HealthDay. All rights reserved.
 
 

Further Reading
Xi E. Zheng, MD, PhD, shares her views on young-onset colorectal cancer at 2014 ACG Annual Scientific Meeting in Philadelphia, PA.
In what could be New York City’s first case of Ebola, a doctor identified by the NY Post as Craig Spencer, 33, MD an emergency medicine physician at New York Hospital/Columbia-Presbyterian was rushed to a special Ebola unit at city-run Bellevue Hospital Center in Manhattan. Spencer returned 10 days ago from a stint as a volunteer with Doctors without Borders, caring for Ebola victims in Guinea, one of three West African nations with major outbreaks.
Patients diagnosed with diabetic retinopathy may be able to get a sense of how their condition has progressed without having to leave the comfort of their own home.
Monitoring devices among intensive care patients set off 2.5 million alarms in one month at a U.S. hospital, a new study of "alarm fatigue" reveals. The research was published online Oct. 22 in PLOS ONE.
While in-office visits may still be best, virtual analysis may be a valuable option in atopic dermatitis care, according to a new study published online Oct. 22 in JAMA Dermatology.
After weight-loss surgery, some patients may be at risk for developing severe headaches, a new study suggests. The report was published online Oct. 22 in Neurology.
The US health care system ranks last compared to other industrialized nations when it comes to affordability and patient access, according to a new survey published in the Oct. 23 issue of the New England Journal of Medicine.
More Reading