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From the Literature: Alzheimer's Disease

Regional Differences in MRI Detection of Amyloid Plaques in AD Transgenic Mouse Brain
Journal: Neuroimage (August 20, 2010)
Authors: Wengenack T, Reyes D, Curran G, et al.
Purpose: To use “five-way anatomic spatial co-registration of MR images with three different histological techniques” to reveal “properties of amyloid plaques in AD transgenic mouse brain… that may explain their variable visibility in gradient- and spin-echo MR images,” as most MRI studies that attempt to detect plaques in AD transgenic mouse brains have “ployed techniques that exploit the paramagnetic effect of iron and have had mixed results.”
Results: In the MR imaging of human AD plaque, MRI methods might eventually be more successful if they rely less on iron magnetic susceptibility effect. This is especially believed by the authors because “human AD plaques more closely resemble the cortical and hippocampal plaques of AD transgenic mice than thalamic plaques.
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Relative Capability of MR Imaging and FDG PET to Depict Changes Associated with Prodromal and Early Alzheimer Disease
Journal: Radiology (September 2010)
Authors: Karow D, McEvoy L, Fennema-Notestine C, et al.
Purpose: “To quantify the effect sizes of regional metabolic and morphometric measures in patients with preclinical and mild Alzheimer disease (AD) to aid in the identification of noninvasive biomarkers for the early detection of AD.”
Results: No evidence was found that flurodeoxyglucose positron emission tomography is more sensitive to preclinical and mild AD degeneration than is MR imaging. Thus, for early detection of AD, MR imaging findings might be more practical as clinical biomarkers.
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Further Reading
Apparently normal older individuals with brain deposits of amyloid beta also show changes in brain structure similar to those seen in Alzheimer's patients.
Are plaques and tangles symptoms of Alzheimer's disease, not the cause?
A new study finds that cotinine reduces the brain plaques associated with dementia.
A case study from the first Alzheimer's pateint to display amyloids on a PET scan sheds light on the pathological course of Alzheimer's disease.
Speaking multiple languages may help protect cognitive health over the long term.
Protein deposits linked to Alzheimer's disease can be triggered by peripheral administration outside the brain.
Altered levels of substances known as biomarkers in spinal fluid may predict the development of Alzheimer’s disease up to 10 years before the condition can be diagnosed based on mental functioning, a new study by researchers in Sweden suggests.
More Reading