HCPLive Network

From the Literature: Alzheimer's Disease

Regional Differences in MRI Detection of Amyloid Plaques in AD Transgenic Mouse Brain
Journal: Neuroimage (August 20, 2010)
Authors: Wengenack T, Reyes D, Curran G, et al.
Purpose: To use “five-way anatomic spatial co-registration of MR images with three different histological techniques” to reveal “properties of amyloid plaques in AD transgenic mouse brain… that may explain their variable visibility in gradient- and spin-echo MR images,” as most MRI studies that attempt to detect plaques in AD transgenic mouse brains have “ployed techniques that exploit the paramagnetic effect of iron and have had mixed results.”
Results: In the MR imaging of human AD plaque, MRI methods might eventually be more successful if they rely less on iron magnetic susceptibility effect. This is especially believed by the authors because “human AD plaques more closely resemble the cortical and hippocampal plaques of AD transgenic mice than thalamic plaques.
Click here to access this thirdy-party resource.

Relative Capability of MR Imaging and FDG PET to Depict Changes Associated with Prodromal and Early Alzheimer Disease
Journal: Radiology (September 2010)
Authors: Karow D, McEvoy L, Fennema-Notestine C, et al.
Purpose: “To quantify the effect sizes of regional metabolic and morphometric measures in patients with preclinical and mild Alzheimer disease (AD) to aid in the identification of noninvasive biomarkers for the early detection of AD.”
Results: No evidence was found that flurodeoxyglucose positron emission tomography is more sensitive to preclinical and mild AD degeneration than is MR imaging. Thus, for early detection of AD, MR imaging findings might be more practical as clinical biomarkers.
Click here to access this thirdy-party resource.


Further Reading
Prenatal and early infant exposure to air pollutants may be linked to developing autism, according to research presented at the American Association for Aerosol Research.
A brain abnormality may be responsible for more than 40% of deaths from sudden infant death syndrome, according to a study published online Nov. 24 in Acta Neuropathologica.
A considerable proportion of patients who did not meet the Seventh Report of the Joint National Committee blood pressure management goals do meet the new goals based on the 2014 expert panel recommendation, according to a study published in the Dec. 2 issue of the Journal of the American College of Cardiology.
More Reading