HCPLive Network

Functional MRI Can Improve Prediction of Cognitive Behavioral Therapy Success

 
FRIDAY, Jan. 4 (HealthDay News) -- Results of functional brain imaging can greatly improve prediction of which patients with social anxiety disorder (SAD) will benefit from cognitive behavioral therapy (CBT), according to a study published in the January issue of JAMA Psychiatry.

Oliver Doehrmann, Ph.D., from the Massachusetts Institute of Technology in Cambridge, and colleagues examined brain responses to angry versus neutral faces or emotional versus neutral scenes using functional magnetic resonance imaging (MRI). This functional MRI data was collected prior to a CBT intervention to predict subsequent response to treatment in 39 medication-free patients meeting Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria for the generalized subtype of SAD. Changes in the Liebowitz Social Anxiety Scale score were measured to assess treatment outcome.

The researchers found that pretreatment responses significantly predicted the subsequent treatment outcome of patients selectively for social stimuli and particularly in regions of higher-order visual cortex. Clinical severity measures combined with the brain measures accounted for more than 40 percent of the variance in treatment response. Using brain measures greatly exceeded predictions based on clinical measures alone at baseline. Potential confounding factors such as depression severity at baseline did not affect prediction success.

"The results suggest that brain imaging can provide biomarkers that substantially improve predictions for the success of cognitive behavioral interventions and more generally suggest that such biomarkers may offer evidence-based, personalized medicine approaches for optimally selecting among treatment options for a patient," the authors write.

Several authors disclosed financial ties to the pharmaceutical industry.
 

Abstract
Full Text (subscription or payment may be required)


Copyright © 2013 HealthDay. All rights reserved.
 

Further Reading
Treatment failure can be caused by a variety of factors, including misdiagnosis of the primary psychiatric complaint, the presence of one or more comorbid conditions, and nonadherence to medication plans.
When treating patients who have been diagnosed with cancer, you should consult with their oncologist to brainstorm interventions that can help your patient have the best possible quality of life.
Prolonged exposure therapy can help veterans with post-traumatic stress disorder overcome the fear, anxiety, and depression that can lead to avoidance behaviors and other responses that negatively impact quality of life.
App will help patients with diabetes log their hypoglycemic events and achieve better control of these events by becoming more aware of preceding signs and symptoms.
Provocative research raises the question of whether we should we look at Alzheimer’s disease as “type 3 diabetes.”
Presentation at CMHC 2014 provides updates on emerging classes of diabetes treatment, including preliminary data from current clinical trials.
In remarks delivered at the American Academy of Family Physicians 2014 Assembly, HHS Secretary Sylvia Mathews Burwell spoke about the ongoing response to the Ebola outbreak, improving health care delivery, the Affordable Care Act, and the Transforming Clinical Practice Initiative.
More Reading