HCPLive Network

“Good” Bacteria Drives Intestinal Response to Infection

Findings from a recent study by Yasmine Belkaid, PhD, and colleagues in the Laboratory of Parasitic Diseases at the National Institute of Allergy and Infectious Diseases (NIAID) have found that “good” bacteria (commensals) that normally live in the intestines may actually help the body defend against infection. The study, which became available online on October 2 in the journal Immunity, describes a way in which T-cells “are regulated to facilitate an immune response to a pathogen” and also explains that researchers found that “during an infection, the DNA of the body’s beneficial bacteria binds to a specific receptor on the intestinal immune cells, called TLR9.” The DNA acted as a natural adjuvant and boosted the activity of T cells so that they could destroy the invading pathogen.

"There is a balance of regulatory immune signals in the body," noted Dr. Belkaid. "During an infection, we’ve found that commensals can break this balance in favor of an infection-fighting response."

Exactly how commensals protect against pathogens has yet to be fully understood. However, if more research can determine how this interaction occurs, it would open up the possibility of using beneficial bacteria as a target for oral therapies against infections and autoimmune diseases.

To read more about this study, click here.

Further Reading
Contamination with multidrug-resistant Acinetobacter baumannii may persist even following terminal cleaning of hospital rooms, according to a study published in the December issue of the American Journal of Infection Control.
Research suggests that bacteria that naturally prey on other bacteria may hold promise in the fight to eradicate antibiotic-resistant bacterial infections.
Specific spectrum of UV light can effectively kill drug-resistant VRE, c. diff, and other sources of serious hospital-associated infections.
The majority of patients with current or recent Clostridium difficile infection receive unnecessary antimicrobials, with 26 percent receiving only unnecessary antimicrobials, according to research published in the February issue of Infection Control and Hospital Epidemiology.
Dosing, the limitations of susceptibility testing, and use of alternate therapies are all discussed in the IDSA's guidelines for treating MRSA infections.
Both restrictive and persuasive measures can be effective for changing antibiotic prescribing behavior in a hospital setting.
Global efforts are needed to curb antibiotic resistance, according to a report published online Nov. 16 in The Lancet Infectious Diseases.
More Reading