HCPLive Network

High Doses of Painkillers Increase Stroke and Cardiac Risks

When taken in high doses, painkillers like Ibuprofen may increase the risk of heart attacks and strokes, according to a review published in the British Medical Journal.
 
The review, titled “Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis” was performed by researchers from Bern University in Switzerland.
 
The team analyzed a number of clinical trials, involving more than 116,000 patients. The goal was to report on the health effects of commonly used painkillers, such as NSAIDs, and anti-inflammatory drugs known as COX-2 inhibitors.
 
More specifically the team studied naproxen, ibuprofen, diclofenac, celecoxib, etoricoxib, rofecoxib, and lumiracoxib.
 
The data demonstrated that the drugs carried risks that were not shown in placebo. For example, Rofecoxib and lumicoxib were associated with twice the risk of heart attack and ibuprofen demonstrated three times the risk of stroke. Four-times the risk of cardiovascular death was associated with Arcoxia and the generic drug diclofenac. Naproxen was shown to be the safest pain killer for those with osteoarthritis, in terms of stroke and cardiac risks.
 
Around the web:
 
Painkillers 'link' to heart attacks
http://hcp.lv/f5zcTG
 
Analysis shows heart, stroke risk of pain drugs
http://hcp.lv/ifrU0i
 
NSAID painkillers linked to increased heart risk
http://hcp.lv/ijZYxq
 
Generic Painkillers May Increase Risk of Heart Attack, Stroke, Review Says
http://hcp.lv/e83e7M
  
Popular painkillers can increase heart attack risks, study shows
http://hcp.lv/ecZjvE
  
 
Pain Medication Complications Video


Further Reading
Professor Francis Chan discusses the risks associated with taking NSAIDs for arthritis pain.
Two drugs show promise in the treatment of active systemic juvenile idiopathic arthritis, according to two studies published in the Dec. 20 issue of the New England Journal of Medicine.
Four in five Australians who use oral non-steroidal anti-inflammatory drugs are unaware of the potential risk factors.
New evidence-based consensus recommendations provide guidance for practitioners on non-surgical treatment options that are appropriate or inappropriate for knee osteoarthritis patients.
The nonsteroidal anti-inflammatory drug (NSAID) diclofenac is associated with significantly increased vascular risk, comparable to that of selective COX-2 inhibitors (coxibs).
Traditional NSAIDs and second-generation NSAIDs (cyclooxygenase-2 inhibitors) are commonly prescribed treatments for a wide range of painful conditions, including acute pain, low back pain, headache, rheumatoid arthritis, and osteoarthritis. However, these medications are also associated with serious gastrointestinal complications and other adverse events.
Gout is one of the most painful forms of chronic arthritis. Successful treatment requires controlling the patient’s uric acid levels, proper selection of the appropriate individualized drug therapy, and patient education to ensure compliance.
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