HCPLive Network

Hyperbaric Oxygen Shows No Benefit for Diabetic Foot Ulcers

THURSDAY, Feb. 28 (HealthDay News) -- For patients with diabetic foot ulcers, use of hyperbaric oxygen (HBO) is not associated with improved healing or with a decrease in the likelihood of amputation, according to a study published online Feb. 19 in Diabetes Care.

David J. Margolis, MD, PhD, from the University of Pennsylvania, in Philadelphia, and colleagues compared the effectiveness of HBO with other conventional therapies in a longitudinal observational cohort study including 6,259 individuals with diabetes, adequate lower limb arterial perfusion, and foot ulcers extending through the dermis.

In propensity score-adjusted models, the researchers found that individuals receiving HBO were significantly less likely to have healing of their foot ulcer (hazard ratio, 0.68) and significantly more likely to have an amputation (hazard ratio, 2.37). HBO was not found to improve the likelihood of wound healing or to reduce the likelihood of amputation in additional analyses including use of an instrumental variable to ascertain the robustness of the results to unmeasured confounding.

"In conclusion, HBO did not appear to be useful for the prevention of amputation and did not improve the likelihood that a wound would heal in a cohort of patients defined by Centers for Medicare and Medicaid Services eligibility criteria," write the authors.

Two authors disclosed financial ties to the National Healing Corp. One of the authors is a consultant to Healogics, which fully owns the National Healing Corporation.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2013 HealthDay. All rights reserved.

Further Reading
Researchers at Hong Kong University and the Wellcome Trust Sanger Institute have identified a link between the influenza A viruses’ genetic diversity and severity of the infection.
Carol Burke, MD, FACG, FASGE, talks about her phase-3 placebo-controlled trial of Celecoxib in pediatric subjects with familial adenomatous polyposis (FAP) at the 2014 ACG Annual Meeting in Philadelphia, PA.
Carol Burke, MD, FACG, FASGE, discusses pediatric familial adenomatous polyposis (FAP) and colorectal cancer at the 2014 ACG Annual Scientific Meeting in Philadelphia, PA.
The immune system is the new focus of much work on traumatic brain injury (TBI). In a challenge to the paradigm that the blood brain barrier prevents harmful leukocytes from entering the brain, a Texas team tried to neutralize the impact of these cells. Peripheral lymphocytes are activated after TBI. They may then act as potential antigen presenting cells and get into the brain, causing cells there to degenerate.
Black women undergoing in vitro fertilization are only about half as likely as white women to become pregnant, and the racial disparity persists even when donor eggs are used. These findings are being presented at the annual meeting of the American Society for Reproductive Medicine, held from Oct. 18 to 22 in Honolulu.
Hospital conversion to for-profit status is associated with improvements in financial margins, but has no effect on process quality metrics or mortality rates, according to a study published in the Oct. 22/29 issue of the Journal of the American Medical Association
Drinking sugar-sweetened sodas may affect cellular aging by shortening telomere length, according to research published online Oct. 16 in the American Journal of Public Health.
More Reading