HCPLive Network

Infectious Agents Cause About One in Six Cancers Worldwide

Wednesday, May 9 (HealthDay News) -- Catherine de Martel, M.D., from the International Agency for Research on Cancer in Lyon, France, and colleagues utilized statistics on estimated cancer incidence in 2008 to calculate the population attributable fraction (PAF) of infectious agents classified as carcinogenic to humans, worldwide and in eight geographic regions. Calculations were based on the prevalence of infection in cancer cases rather than in the general population, when the associations were very strong.

The researchers found that, of the 12.7 million new cancer cases that occurred in 2008, the PAF for infectious agents was 16.1 percent. This represented about two million new cases. The fraction of infection-attributable cancers was higher in less developed countries than in more developed countries (22.9 versus 7.4 percent). Approximately 1.9 million cases of gastric, liver, and cervix uteri cancers were caused by Helicobacter pylori, hepatitis B and C viruses, and human papillomaviruses. Cervix uteri cancer accounted for about half of the infection-related burden of cancer in women, while liver and gastric cancers accounted for more than 80 percent in men. Younger people (<50 years) were affected by approximately 30 percent of infection-attributable cases.

"Around two million cancer cases each year are caused by infectious agents," the authors write. "Application of existing public health methods for infection prevention, such as vaccination, safer injection practice, or antimicrobial treatments, could have a substantial effect on the future burden of cancer worldwide."

Abstract
Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)

Globally, nearly two million new cancer cases are caused by infectious agents each year, according to a study published online May 9 in The Lancet Oncology.


Copyright © 2012 HealthDay. All rights reserved.


Further Reading
Researchers at Hong Kong University and the Wellcome Trust Sanger Institute have identified a link between the influenza A viruses’ genetic diversity and severity of the infection.
Carol Burke, MD, FACG, FASGE, talks about her phase-3 placebo-controlled trial of Celecoxib in pediatric subjects with familial adenomatous polyposis (FAP) at the 2014 ACG Annual Meeting in Philadelphia, PA.
Carol Burke, MD, FACG, FASGE, discusses pediatric familial adenomatous polyposis (FAP) and colorectal cancer at the 2014 ACG Annual Scientific Meeting in Philadelphia, PA.
The immune system is the new focus of much work on traumatic brain injury (TBI). In a challenge to the paradigm that the blood brain barrier prevents harmful leukocytes from entering the brain, a Texas team tried to neutralize the impact of these cells. Peripheral lymphocytes are activated after TBI. They may then act as potential antigen presenting cells and get into the brain, causing cells there to degenerate.
Black women undergoing in vitro fertilization are only about half as likely as white women to become pregnant, and the racial disparity persists even when donor eggs are used. These findings are being presented at the annual meeting of the American Society for Reproductive Medicine, held from Oct. 18 to 22 in Honolulu.
Hospital conversion to for-profit status is associated with improvements in financial margins, but has no effect on process quality metrics or mortality rates, according to a study published in the Oct. 22/29 issue of the Journal of the American Medical Association
Drinking sugar-sweetened sodas may affect cellular aging by shortening telomere length, according to research published online Oct. 16 in the American Journal of Public Health.
More Reading