HCPLive Network

Kynamro Approved for Genetic Condition Tied to Cholesterol

 
WEDNESDAY, Jan. 30 (HealthDay News) -- Kynamro (mipomersen sodium) has been approved by the U.S. Food and Drug Administration to treat homozygous familial hypercholesterolemia (HoFH), a rare inherited condition in which the body can't remove low-density lipoprotein (LDL) cholesterol from the blood, as an addition to lipid-lowering medications and diet.

Many people with HoFH have a heart attack and die before age 30, the FDA said in a news release. HoFH affects approximately one in every one million people in the United States. Kynamro is a once-weekly injection designed to lower creation of blood lipid particles that ultimately form LDL, the agency said.

The drug was clinically evaluated among 51 people with HoFH. Among Kynamro users, LDL levels fell an average of about 25 percent during the first 26 weeks, the FDA said. The drug will carry a "black box" label warning of possible liver abnormalities that could lead to progressive liver disease.

More common side effects noted during clinical testing included injection-site reactions, flu-like symptoms, nausea, headache, and elevated liver enzymes.

Kynamro is produced by Genzyme Corp., of Cambridge, Mass.
 

More Information


Copyright © 2013 HealthDay. All rights reserved.
 
 

Further Reading
John Saltzman, MD, Discusses the gastrointestinal tract and its part in the functioning of the body.
Type 2 diabetes occurs at roughly the same prevalence in men and women. Despite the similar prevalence in the sexes, women who develop diabetes feel the effect of its complications disproportionately.
Research presented at the European League Against Rheumatism’s Annual Meeting indicates comorbid diabetes may be linked to increased osteoarthritis pain.
Analysis of a dozen phase III trials indicates that patients with atrial fibrillation face significantly less risk of major, fatal, and intracranial bleeding if they take target-specific oral anticoagulants rather than vitamin K antagonists.
Calculation and interpretation of the anion gap is extremely useful in the evaluation and treatment of the patient with metabolic acidosis. In this installment, we look at case examples involving patients with multiple sclerosis and urosepsis; COPD, diabetes, and renal failure; and type 1 diabetes.
The US Department of Homeland Security (DHS) will begin limiting the airports through which travelers from Ebola-stricken countries may enter the US. Starting tomorrow, all these passengers will be forced to fly through 5 US airports: JFK International in New York, Newark Liberty International in Newark, NJ, Washington Dulles International in Dulles, VA, Hartsfield-Jackson International in Atlanta, GA, and Chicago O’Hare International in Chicago, Ill.
At least one-third of common symptoms have no disease-related explanation, according to a narrative review published in the Oct. 21 issue of the Annals of Internal Medicine.
More Reading