In an effort to examine unnecessary antimicrobial use, Megan K. Shaughnessy, M.D., of the Minneapolis Veterans Affairs Health Care System, and colleagues performed a retrospective review of pharmacy and medical records for 246 patients diagnosed with new-onset CDI.The researchers found that, during and/or after CDI treatment, 57 percent of patients with new-onset CDI received non-CDI antibiotics. More than three-quarters (77 percent) of all patients received at least one dose of unnecessary antimicrobials, and 26 percent received only unnecessary antimicrobials. Unnecessary antimicrobials were included in 45 percent of the total non-CDI antimicrobial days. The most commonly cited reasons for antimicrobial use included suspected pneumonia or urinary tract infection. Fluoroquinolones and β-lactam antibiotics were most often used.