HCPLive Network

Most Patients with C. difficile Infection Receive Unnecessary Antimicrobials

 
MONDAY, Jan. 21 (HealthDay News) -- The majority of patients with current or recent Clostridium difficile infection (CDI) receive unnecessary antimicrobials, with 26 percent receiving only unnecessary antimicrobials, according to research published in the February issue of Infection Control and Hospital Epidemiology.

In an effort to examine unnecessary antimicrobial use, Megan K. Shaughnessy, M.D., of the Minneapolis Veterans Affairs Health Care System, and colleagues performed a retrospective review of pharmacy and medical records for 246 patients diagnosed with new-onset CDI.

The researchers found that, during and/or after CDI treatment, 57 percent of patients with new-onset CDI received non-CDI antibiotics. More than three-quarters (77 percent) of all patients received at least one dose of unnecessary antimicrobials, and 26 percent received only unnecessary antimicrobials. Unnecessary antimicrobials were included in 45 percent of the total non-CDI antimicrobial days. The most commonly cited reasons for antimicrobial use included suspected pneumonia or urinary tract infection. Fluoroquinolones and β-lactam antibiotics were most often used.

"Non-CDI antimicrobials are often used unnecessarily in patients with a current or recent history of CDI," the authors write. "This suggests that, during this window of heightened risk of CDI recurrence, a large portion of non-CDI antimicrobial use could be avoided, thereby presumably mitigating some of the associated recurrence risk."

One author disclosed financial ties to the pharmaceutical industry.
 

Abstract
Full Text (subscription or payment may be required)


Copyright © 2013 HealthDay. All rights reserved.
 
 

Further Reading
A new system designed to reduce pathogens in donated blood plasma and reduce the risk of transfusion-transmitted infections has been approved by the US Food and Drug Administration.
Frequenting roller-coaster rides may lead to intimal tears within the cervical internal carotid artery (ICA), according to a case report published online Nov. 26 in Pediatric Neurology.
For patients at high risk of cardiovascular disease, resting heart rate can predict renal outcomes, according to research published online Nov. 27 in the Journal of Internal Medicine.
More Reading