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Overweight Black Women with Knee Osteoarthritis Face Increased Risk of Poor Outcomes

Pain Management   |   Primary Care   |   Rheumatology   |  
 
WEDNESDAY, Jan. 23 (HealthDay News) -- Overweight African-American women with or at risk of knee osteoarthritis are at higher risk than overweight white women of poor functional outcomes, according to a study published in the January issue of Arthritis Care & Research.

Carmelita J. Colbert, M.D., from Northwestern University in Chicago, and colleagues analyzed whether excess body weight was associated with poorer four-year functional outcomes (as determined by the Western Ontario and McMaster Universities Osteoarthritis Index function, 20-meter walk and chair stand performance) in African-Americans compared with whites in 3,695 patients (16.1 percent African-American) with or at higher risk for knee osteoarthritis.

The researchers found that a higher body mass index and large waist circumference correlated with poorer outcomes. Among women with either feature, African-American women had a higher risk of poor outcomes, after adjusting for age, education, and income. The findings were potentially explained by income, comorbidity, depressive symptoms, pain, and disease severity. For men, findings were less consistent and were potentially explained by age and knee pain.

"Among Osteoarthritis Initiative women with excess body weight, African-Americans are at greater risk than whites for poor four-year outcome," Colbert and colleagues conclude. "Modifiable factors that may help to explain these findings in the Osteoarthritis Initiative include comorbidity, depressive symptoms, and knee pain."

The study was partially funded by Merck, Novartis, GlaxoSmithKline, and Pfizer as part of the Osteoarthritis Initiative, a public-private partnership.
                           

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Further Reading
For adults with symptomatic knee osteoarthritis, vitamin D supplementation for two years does not reduce knee pain or cartilage volume loss compared to placebo, according to a study published in the Jan. 9 issue of the Journal of the American Medical Association.
In persons with or at risk for radiographic knee osteoarthritis, African-Americans are 72 to 76 percent less likely than whites to meet the 2008 United States Department of Health and Human Services Physical Activity Guidelines aerobic component, according to a study published in the February issue of Arthritis Care & Research.
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