HCPLive Network

Overweight Black Women with Knee Osteoarthritis Face Increased Risk of Poor Outcomes

 
WEDNESDAY, Jan. 23 (HealthDay News) -- Overweight African-American women with or at risk of knee osteoarthritis are at higher risk than overweight white women of poor functional outcomes, according to a study published in the January issue of Arthritis Care & Research.

Carmelita J. Colbert, M.D., from Northwestern University in Chicago, and colleagues analyzed whether excess body weight was associated with poorer four-year functional outcomes (as determined by the Western Ontario and McMaster Universities Osteoarthritis Index function, 20-meter walk and chair stand performance) in African-Americans compared with whites in 3,695 patients (16.1 percent African-American) with or at higher risk for knee osteoarthritis.

The researchers found that a higher body mass index and large waist circumference correlated with poorer outcomes. Among women with either feature, African-American women had a higher risk of poor outcomes, after adjusting for age, education, and income. The findings were potentially explained by income, comorbidity, depressive symptoms, pain, and disease severity. For men, findings were less consistent and were potentially explained by age and knee pain.

"Among Osteoarthritis Initiative women with excess body weight, African-Americans are at greater risk than whites for poor four-year outcome," Colbert and colleagues conclude. "Modifiable factors that may help to explain these findings in the Osteoarthritis Initiative include comorbidity, depressive symptoms, and knee pain."

The study was partially funded by Merck, Novartis, GlaxoSmithKline, and Pfizer as part of the Osteoarthritis Initiative, a public-private partnership.
                           

Abstract
Full Text

Copyright © 2013 HealthDay. All rights reserved.
 
 

Further Reading
The number of invasive diagnostic procedures, including amniocentesis, is down significantly after the introduction of noninvasive prenatal testing, according to a study published in the January issue of the Journal of Clinical Ultrasound.
For obese hyperinsulinemic children, metformin seems to decrease perceived hunger and increase perceived fullness, according to a study published online Dec. 8 in Diabetes, Obesity and Metabolism.
Rosa Michaelis, MD, discusses her goals of cultivating more patient interaction within epilepsy research at the American Epilepsy Society 2014 Annual Meeting.
More Reading