HCPLive Network

Phase III Study Results for Levomilnacipran Promising

Forest Laboratories and Pierre Fabre Medicament made an announcement today stating that the main goal of their phase three study for levomilnacipran, a possible future treatment of major depressive disorder (MDD), had been achieved.

These recent findings are a relief for the two developmental partners as well as the medical community, especially since a previous phase three study earlier this year of levomilnacipran failed to exhibit optimistic results; the findings of that study showed that the drug decreased depression no more effectively than a placebo.

The purpose of this double-blind, randomized, placebo-controlled study was to test the drug's efficacy, safety, and tolerability.

The eight-week trial focused on 720 patients, whose depression was measured by the six-point Montgomery-Asberg Depression Rating Scale (MADRS). The researchers found that levomilnacipran decreased the depression of the participants, and further, they discovered that the participant’s scores lowered as doses increased.

MDD is estimated to affect roughly fifteen-million people in the United States each year.

"Depressed patients often struggle to find the right antidepressant and the need for new medications is high," said Dr. Marco Taglietti, Forest president and senior vice president of research and development.

The drug works through inhibiting the re-uptake of norepinephrine and serotonin, which increases the levels of these two neurotransmitters that are known to affect mood.

"These positive Phase III results are very encouraging and support the continued research of levomilnacipran in adult patients with major depressive disorder," concluded Taglietti.
 

Further Reading
Patients with advanced colorectal cancer previously only had access to limited treatment options; however, new research presented at the 26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics in Barcelona, Spain, indicated a combination of 3 targeted drugs could potentially serve as a successful treatment.
As children get older their waistlines increasingly show signs of getting wider as well and the problem extends far beyond American students. Doctors around the world are working together to find ways to combat the growing problem.
Doctors are taking a new look at a condition which could play a factor in predicting cardiovascular incidents called hopelessness. While not much is known about the condition or treatment there are some things people can do to keep themselves as healthy as possible.
More Reading