HCPLive Network

Researchers Find Genetic Connection to Rheumatoid Arthritis

Researchers in China have found evidence of genetic links to rheumatoid arthritis (RA) and the related condition ankylosing spondylitis (AS), according to provisional results reported online last Friday in the journal Arthritis Research & Therapy.
 
In a previous study, the researchers found increased expression of the gene TXNDC5 in the synovial tissues of patients with RA. Now they have investigated whether single nucleotide polymorphisms (SNPs), or sections of genetic material where a single letter of the genetic code is frequently mutated, in and near the same gene are linked with development of RA or AS.
 
The researchers looked at 96 SNPs in or near the TXNDC5 gene in 267 patients with RA, 51 patients with AS, and 160 healthy patients. In addition, they looked at four SNPs for 951 RA patients and 898 healthy patients. The results: Nine SNPs were found to be significantly associated with RA, and 16 SNPs were found to be significantly associated with AS.
 
Around the Web
 
Investigating a pathogenic role for TXNDC5 in rheumatoid arthritis (provisional abstract) [Arthritis Research & Therapy] 


Further Reading
A second biologic option is now available for patients in New Zealand with forms of arthritis.
The FDA declined to approve Simponi (golimumab) for use in limiting the advance of structural damage in patients with moderate to severe rheumatoid arthritis.
Tumor necrosis factor-α antagonists used to treat autoimmune diseases such as rheumatoid arthritis may pose less risk of serious infection than previously thought, a new study suggests.
European Union okays Vimovo for osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis
Though physicians are already aware that rheumatoid arthritis (RA) and ankylosing spondylitis (AS) cause inflammation in joints, tendons, and surrounding muscle tissues, the effects of those chronic autoimmune disorders on stiffness, strength, and function of the patellar tendon have not yet been determined.
Ankylosing Spondylitis patients appear to be highly susceptible to Inflammatory Bowel Disease, including Crohn's disease.
Finnish researchers have discovered connections between rheumatoid arthritis and certain work occupations.
More Reading