HCPLive Network

Researchers Identify Features of Serious Pertussis Progression in Infants

FRIDAY, Jan. 18 (HealthDay News) -- Rapidly rising white blood cell (WBC) counts and high heart rates and respiratory rates may indicate more serious pertussis progression in infants, according to research published online Jan. 10 in the Journal of the Pediatric Infectious Diseases Society.

Erin L. Murray, Ph.D., from the California Department of Public Health in Richmond, and colleagues reviewed medical records for 31 infants who were ≤90 days of age and hospitalized for pertussis in five Southern California pediatric intensive care units (from Sept. 1, 2009, through June 30, 2011) to obtain demographic and clinical information.

The researchers found that eight of the infants had more severe infections, six had pulmonary hypertension, and four died. Compared with less severe illness, more severe illness was characterized by WBC counts exceeding 30,000, heart rates exceeding 170, and respiratory rates exceeding 70 more rapidly after cough onset.

Our data suggest that a predictor of more severe Bordetella pertussis disease in young infants is an elevated and rapidly rising WBC count, making early and serial WBC count determinations critical to the evaluation of all infants with suspected or proven pertussis," the authors write. "Furthermore, close monitoring of heart and respiratory rates is imperative because these were demonstrated to correlate with more severe disease progression."

Full Text (subscription or payment may be required)

Copyright © 2013 HealthDay. All rights reserved.

Further Reading
The 2010 pertussis outbreak in California may have been related to parents’ refusal to vaccinate their school-aged children, according to a new study published in Pediatrics.
In this podcast, experts from the CDC discuss tetanus, diphtheria, and acellular pertussis vaccine recommendations for adolescents.
Improve your knowledge of vaccinations with these CME activities, which cover issues such as cocooning, business practices, and evidence-based decision making.
Session at Pri-Med Southwest focuses on the current epidemiology of pertussis and updated vaccine recommendations.
Evidence-based guidelines have been developed for adult patients with sickle cell disease and pulmonary hypertension. The guidelines have been published in the March 15 issue of the American Journal of Respiratory and Critical Care Medicine.
Immunizing older adults with the tetanus-diphtheria-acellular pertussis vaccine appears to be safe, according to a study published online Nov. 28 in Clinical Infectious Diseases.
Suma Jain, MD, a pulmonologist at the Ochsner Clinic Foundation, provides a clinical update on the diagnosis and treatment of pulmonary hypertension (PH).
More Reading