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Atherosclerosis

News from the literature on a possible link between atherosclerosis and psoriasis and quality of life for patients with this skin condition.
Heart trouble can start early for obese children, a German research team found. Writing in the Journal of the American College of Cardiology, Norman Manger, MD, and colleagues compared blood pressure, low-density lipoprotein cholesterol, and glucose metabolism in 61 obese children with that of 40 children with healthy weights. The obese group had an average BMI of about 31 while the control group’s average BMI was about 20.
For patients with heterozygous familial hypercholesterolemia, statin therapy is often not enough to reduce LDL cholesterol. In two articles in The Lancet, researchers report on promising results of two international Phase 3 trials of evolocumab. The drug is a monoclonal antibody to proprotein convertase sudbtilism/kexin type 9 (PCSK9).
For individuals with hypercholesterolemia, research published in the Journal of American Medical Association provided recommendations on statin use for treating their condition prior to age 80.
Long-term statin use among children with familial hypercholesterolemia is associated with normalization of carotid intima-media thickness progression, according to a research letter published online Sept. 9 in the Journal of the American Medical Association.
Patients who do not have coronary artery disease but have fat around their hearts appear more likely to develop atherosclerosis, a team of researchers in Germany found.
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