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Cardiovascular risk related to severity of inflammation, but not associated with disease duration
Among patients with hypertension, elevated systolic blood pressure is associated with the highest risk for cardiovascular events, although once SBP is below 140, lowering it below 120 does not further reduce the risk of cardiovascular events, according to a study published June 16 in JAMA Internal Medicine.
Patients with type 2 diabetes and inadequate glycemic control treated with dapagliflozin plus metformin and sulfonylurea experienced sustained improvements in HbA1c, fasting plasma glucose, weight loss, and systolic blood pressure over 52 weeks.
Patients between the ages of 55 and 80 with type 2 diabetes treated with canagliflozin for more than 100 weeks experienced significant reductions in HbA1C, fasting plasma glucose, bodyweight, and systolic blood pressure.
Although patients who would have been considered high risk 10 years ago can now successfully undergo percutaneous cardiac intervention, those with severe sclerotic lesions in the ascending aorta still present a challenge to surgeons.
Severe coronary calcification is an independent predictor of worse prognosis in obstructive coronary artery disease patients undergoing percutaneous coronary intervention.
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