HCPLive Network

Opioid-induced Constipation

Treatment with the oral, peripherally acting µ-opioid receptor antagonist naloxegol is safe and effective for opioid-induced constipation, according to a study published online June 4 in the New England Journal of Medicine.
Patients with IBS-D in two phase II trials of eluxadoline experienced sustained improvements in abdominal pain and bowel symptoms at 26 weeks of treatment, with mild side effects.
Though constipation as a side effect of opioid therapy is generally considered a tolerability issue that can be treated with over-the-counter laxatives, opioid-induced constipation may still lead to serious gastrointestinal complications.
Preliminary research data revealed a significantly higher incidence of opioid-induced constipation among patients taking opioid analgesics for chronic non-cancer pain than self-reported constipation complaints suggest.
Administering drops of the probiotic supplement Lactobacillus reuteri protectis in healthy infants results in fewer instances of colic, acid reflux, and constipation compared to placebo.
Following a low-FODMAPs diet reduced symptoms for patients suffering from IBS, according to a study of 38 patients. Unfortunately,the diet might not be realistic for all IBS patients to take on.
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