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Studies Show Little to No Effect on Cardiovascular Health from Testosterone Replacement Therapy
At least 5 studies indicating that testosterone replacement therapy either has no effect on cardiovascular health -- or tends to improve it -- appeared during the 3-week period immediately after the US Food and Drug Administration's controversial decision to mandate warnings about the potential cardiovascular risks of such treatment.
Researchers have long known that single men tend to have more testosterone than comparable men in long-term relationships, but what about men in new relationships? A new study finds that testosterone generally remains at “single-man” levels until couples have been dating for more than a year.
Testosterone supplements don't improve ejaculatory function in men with low testosterone, according to research published online July 9 in the Journal of Clinical Endocrinology & Metabolism.

A review of research on the use of testosterone replacement therapy in men with a history of prostate cancer and in men with elevated prostate cancer risk found no evidence of statistically significant associations between such treatment and cancer progression.
Men with borderline testosterone levels frequently have depression and depressive symptoms, according to a study published online June 30 in the Journal of Sexual Medicine.

Endocrine regulation in ejaculation control is still not well understood. Sex steroids (testosterone and estradiol), pituitary (prolactin and oxytocin), and thyroid hormones may regulate the ejaculatory process, but exact mechanisms are unclear.
A research review concludes that older men who receive testosterone replacement via injection may enjoy greater benefits and face fewer risks than those who use transdermal or oral testosterone formulations.

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