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Major Depressive Disorder
The MD Magazine Major Depressive Disorder condition center provides clinical news and articles, information about upcoming conferences and meetings, updated clinical trial listings, and other resources.

Latest Headlines

Study results suggest that more than 80% of patients with depression in the general population appear to not be eligible for clinical trials of antidepressant medications.
An article in Schizophrenia Bulletin makes a strong case for a scaling up of schizophrenia care that could yield breakthroughs in treatment for the condition and, ultimately, many other mental health disorders. Such a scaling up would involve breaking down significant barriers but could yield significant breakthroughs in treatment.
A study in Translational Psychiatry has identified three potential genes that could prove to be responsible for disturbances in mitochondrial function and DNA repair mechanisms in bipolar disorder. The genes in question – POLG, OGG1, and NDUFV2 – may open new targets for examination. The study authors themselves consider the results to be “somewhat promising.”
Children with systemic lupus erythematosus (SLE)/mixed connective tissue disease (MCTD) often suffer from significant bouts of depression and potentially suicide ideation, a study in the Journal of Pediatrics determined.
Internet-based cognitive behavioral therapy (ICBT) could be useful for adolescents with anxiety disorders in combination with standard treatment delivered in child and adolescent psychiatric clinics, according to preliminary conclusions from the study.
Two comprehensive reviews in the Indian Journal of Psychiatry looked at the use of pharmacologic therapy for psychiatric conditions during pregnancy and lactation. One review looked at mood stabilizers and the other focused on antidepressants, anxiolytics, and hypnotics.
Researchers seek to determine whether depression subtype is an useful predictor of which medication regimen might be most effective in treating patients with those subtypes.

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