With 259 million painkiller prescriptions written in 2012 alone, according to the Centers for Disease Control and Prevention (CDC), one of the most common side effects experienced by patients being treated for chronic pain is opioid-induced constipation (OIC).
Knee osteoarthritis (OA) sufferers experience more than just pain and changes to their cartilage, bone, ligaments, and muscles in the surrounding area. They also often experience changes in the sensory and motor function of the knee.
Spend any appreciable time on PubMed, Medline, or Embase, and you can begin to think that there aren’t many untapped areas of clinical exploration. Nothing could be further from the truth, of course, and a recent clinical review in Arthritis Research and Therapy outlines some of the uncharted territory even in a condition as prevalent as osteoarthritis of the knee.