Peptic Ulcer

The Rome Foundation announced the release of updated and revised Rome IV diagnostic criteria for more than 20 different gastrointestinal disorders at DDW 2016.

The molecular mechanism permitting the bacterium Helicobacter pylori (H. pylori) to survive in nearly 50% of humans' stomachs has been identified, according to research published in Science Advances

China's type 2 diabetes mellitus (T2DM) epidemic continues to be a pervasive, costly health care issue, with proportions surpassed only by epidemic here in the US. The majority of T2DM treatment guidelines recommend metformin as the first-line anti-hyperglycemic agent for diabetes management due to its relative safety, tolerability, and cost-effectiveness.

Agent Orange exposure several decades earlier may increase morbidity from various diseases, some of which have rarely been explored in previous epidemiologic studies.

Although they are revolutionary for the treatment of various gastric acid-related disorders, proton pump inhibitors may be linked to interstitial nephritis, according to research published in Kidney International.

With 10% of Americans contracting ulcers, pharmacists can be a valuable source of education for patients regarding the causes of peptic ulcer and the pros and cons of available treatments.

Patients on antithrombotic therapy must be monitored for increased risk of upper GI bleeding.

Acid reduction from PPI treatment may alter bacterial flora in the digestive system, which may increase an individual's susceptibility to infection.

Researchers in Denmark evaluated the quality of hospital care delivered to more than 13,500 patients with peptic ulcer bleeding as part of a large-scale quality improvement initiative.

New measures enhance practices' ability to track and improve performance and quality.

Researchers have developed a pig model that mimics the human immune response to H. pylori infection, enabling them to better predict the progression and outcomes of infection.

A recent meta-analysis indicates treatment with oral proton pump inhibitors (PPIs) produces outcomes similar to those obtained with treatment with intravenous PPIs in patients with peptic ulcer bleeding.

Even when it's administered in a low-dose form that resists gastric acid and prevents tablet dissolution in the stomach, aspirin therapy causes peptic ulcer and increases the risk of 30-day mortality resulting from gastrointestinal (GI) disorder progression.

Though they conducted their analysis in China, four researchers have successfully demonstrated a link between babA2 gene and peptic ulcer disease (PUD) in Helicobacter pylori-infected populations within countries located on the Western Hemisphere.

Research findings underscore the importance of testing peptic ulcer patients for H. pylori status.

Though it's common medical knowledge that an ulcer eating a hole through a patient's stomach requires immediate surgical treatment as a result of its life-threatening nature, new findings from a team of Danish researchers urge physicians to beat the clock in performing emergency surgery on perforated peptic ulcers (PPU).

Prolonged treatment with combination antibiotics and proton pump inhibitors resulted in an eradication rate of greater than 90% in treated patients.

Study supports the current practice of post-surgery H. pylori eradication in patients with perforated peptic ulcers.

Genome studies provide clues about variation in individual risk for H. pylori infection.

Researchers comparing scoring systems find considerable variation in performance and several factors that complicate direct comparison of systems.

After noticing the ample adverse effects of second-line Helicobacter pylori eradication treatments that utilize tetracycline, furazolidone and proton-pump inhibitors, one group of gastroenterologists set to work adding a probiotic compound to the regimen in an attempt to increase the stomach bacteria's eradication rate while curbing those unwanted effects.

Results from a mouse model study suggest that altering host gut microbiota via antibiotic treatment may reduce inflammation and other pathologies caused by H. pylori.

Researchers investigating the development of peptic ulcers in patients with liver cirrhosis reported that H. pylori is not the predominant etiology in this population.

Researchers in Taiwan report that type 2 diabetes is independently associated with increased risk of peptic ulcer bleeding.

Researchers report that certain classes of comorbidities increase mortality risk in patients with peptic ulcer bleeding, but the presence of any comorbidities also affects mortality risk.

A retrospective review of records from a large medical database finds that patients with sleep apnea face a substantially higher risk of developing peptic ulcer.

Expert advice from the 2013 AGA-ASGE Clinical Congress of Gastroenterology and Hepatology on managing diarrhea, constipation, abdominal pain, and other symptoms associated with irritable bowel syndrome (IBS).

Julie Parsonnet, MD, discussed well-established links between infectious disease and chronic disease and microorganisms disappearing from the human microbiome.

A few weeks ago I blogged how great it was to sleep in on a Saturday. Well, this past Saturday was different.

Scientists in Japan have developed a new yogurt that includes an antibody that significantly reduced levels of ulcer-producing bacteria in study participants.