HCPLive Network

Three New Treatments Show Promise for Parkinson's Disease

FRIDAY, March 15 (HealthDay News) -- Three new treatments show promise for patients with Parkinson's disease, according to three studies to be presented at the annual meeting of the American Academy of Neurology, held from March 16 to 23 in San Diego.

Stuart Isaacson, MD, from the University of South Florida, in Tampa, and colleagues randomized 225 patients with Parkinson's disease to receive placebo or droxidopa, an oral pro-drug converted to norepinephrine, for an eight-week treatment period. The researchers found that, at week one, patients receiving droxidopa experienced significant improvement in dizziness/lightheadedness, with a trend toward improvement at week eight. There was a significant improvement in standing systolic blood pressure at week one with droxidopa, and a numerical improvement at week eight.

C. Warren Olanow, MD, from the Mount Sinai School of Medicine, in New York City, and colleagues randomized 337 patients with stable dosages of levodopa to tozadenant (60, 120, 180, or 240 mg twice daily) or placebo. The researchers found that patients in the 120 mg and 180 mg tozadenant groups experienced significant reductions in OFF time at 12 weeks, compared with baseline, with no increase in ON time with troublesome dyskinesia. In a third study, Robert A. Hauser, MD, of the University of South Florida, in Tampa, and colleagues found that, for patients receiving dopamine agonist monotherapy with suboptimal symptom control, treatment with add-on rasagiline resulted in a significant improvement in the Unified Parkinson's Disease Rating Scale (UPDRS) score and in UPDRS-motor scores compared with placebo.

"All of these treatments are promising news for people with Parkinson's disease, which is the second most common neurodegenerative disease after Alzheimer's disease," Hauser said in a statement.

The first, second, and third studies were funded by Chelsea Therapeutics, Biotie Therapies, and Teva Pharmaceuticals, respectively.

Abstract - Isaacson
Abstract - Olanow
Abstract - Hauser
More Information

Copyright © 2013 HealthDay. All rights reserved.

Further Reading
Even though the active ingredient in marijuana can be associated with memory impairment, it may slow or halt Alzheimer’s disease.
Peripheral neuropathy was found in a third of HIV patients in a recent study of 58 men with a median age of 36 years.
Men who are socially well-integrated show more than a 2-fold reduced risk of suicide, according to a longitudinal study published in the Annals of Internal Medicine.
The costs of Medicare associated with Sovaldi (sofosbuvir), an emerging hepatitis C drug, will vary depending on how many people are given the treatment, a blog in Health Affairs found.
The European Commission (EU) has granted Bristol-Myers Squibb’s Daklinza (daclatasvir) approval for an all-oral drug regimen for the treatment of four genotypes of chronic hepatitis C infection.
While the US Preventive Services Task Force does not recommend screening for hepatitis B virus infection in asymptomatic persons in the general population, a recent update focuses on identifying those who are high risk and should be screened.
The Ebola outbreak in West Africa continues to expand and around the world researchers are striving to learn more about the disease and how to stop it to ensure that any future outbreaks of the virus are not nearly as severe.
More Reading
Even though the active ingredient in marijuana can be associated with memory impairment, it may slow or halt Alzheimer’s disease.