HCPLive Network

Hyponatremia Produces Poor Outcomes in Acute-on-Chronic Liver Failure

Drawing upon data from a large European study, Andrés Cárdenas, MD, reported an association between hyponatremia and acute-on-chronic liver failure (ACLF) during a poster session at the 2013 annual meeting of the American Association for the Study of Liver Diseases held November 1-5, 2013, in Washington, DC.
 
Cirrhosis patients who experience ACLF may face poor short-term survival. The condition is characterized by a systemic inflammatory response, with acute decompensation and organ failure.
 
For their poster, Cárdenas and colleagues from the Institute of Digestive Diseases and Metabolism at the Hospital Clinic and University of Barcelona examined data from the CLIF Acute-on-Chronic Liver Failure in Cirrhosis Study (CANONIC) to determine whether hyponatremia has prognostic value in cirrhotic patients with and without ACLF.
 
The CLIF CANONIC database included the health records of 1,341 consecutive patients at 29 different European centers who presented with acute decompensation of cirrhosis of the liver.
 
Of the 517 patients with acute compensation of cirrhosis available for the study’s 28-day follow-up period, 217 (42.0%) had ACLF at enrollment, while 300 (58.0%) were free of ACLF when they enrolled. Of the group with ACLF, 48 (22.1%) had hyponatremia, which was defined as serum sodium <130meq/L. No hyponatremia was seen in 179 (78.9%) of the ACLF patients.


Further Reading
Otezla (apremilast) is an oral, selective phosphodiesterase 4 (PDE4) inhibitor for the treatment of patients with moderate to severe plaque psoriasis for whom phototherapy or systemic therapy is appropriate.
New research from Northwestern University has found that schools are woefully unprepared to deal with anaphylaxis and other life-threatening emergencies stemming from student allergies.
New research indicates that doctors who treat anaphylaxis with intravenous epinephrine rather than intramuscular or subcutaneous injections are increasing the risk that patients will suffer overdoses or other adverse reactions.
Anil Asgaonkar, MD, provides a basic overview of the signs, symptoms, and causes frequently associated with hyponatremia, and outlines several standard treatment approaches.
Researchers in Wisconsin recently announced the discovery of a gene which could help explain certain traits seen in patients diagnosed with diabetes.
Primary care providers perceive multiple barriers to provision of genetics services for their patients, according to research published online Sept. 11 in Genetics in Medicine.
The need for more doctors continues to be one of the most pressing needs in the US healthcare system. However, some types of specialists are more in-demand than others.
More Reading
Otezla (apremilast) is an oral, selective phosphodiesterase 4 (PDE4) inhibitor for the treatment of patients with moderate to severe plaque psoriasis for whom phototherapy or systemic therapy is appropriate.