HCPLive Network

Hyponatremia Produces Poor Outcomes in Acute-on-Chronic Liver Failure

Drawing upon data from a large European study, Andrés Cárdenas, MD, reported an association between hyponatremia and acute-on-chronic liver failure (ACLF) during a poster session at the 2013 annual meeting of the American Association for the Study of Liver Diseases held November 1-5, 2013, in Washington, DC.
 
Cirrhosis patients who experience ACLF may face poor short-term survival. The condition is characterized by a systemic inflammatory response, with acute decompensation and organ failure.
 
For their poster, Cárdenas and colleagues from the Institute of Digestive Diseases and Metabolism at the Hospital Clinic and University of Barcelona examined data from the CLIF Acute-on-Chronic Liver Failure in Cirrhosis Study (CANONIC) to determine whether hyponatremia has prognostic value in cirrhotic patients with and without ACLF.
 
The CLIF CANONIC database included the health records of 1,341 consecutive patients at 29 different European centers who presented with acute decompensation of cirrhosis of the liver.
 
Of the 517 patients with acute compensation of cirrhosis available for the study’s 28-day follow-up period, 217 (42.0%) had ACLF at enrollment, while 300 (58.0%) were free of ACLF when they enrolled. Of the group with ACLF, 48 (22.1%) had hyponatremia, which was defined as serum sodium <130meq/L. No hyponatremia was seen in 179 (78.9%) of the ACLF patients.


Further Reading
Medical patients sometimes hear what we say skeptically, but Americans in general will believe any darn thing.
Bristol-Myers Squibb announced today the US Food and Drug Administration (FDA), had granted approval for Evotaz tablets in combination with other antiretroviral agents for an innovative treatment option for adults suffering from HIV-1 infection – delivering proven suppression through 48 weeks.
Researchers have found that menopause typically begins 2 to 4 years earlier in women with high levels of certain chemicals found in household items, personal care products, plastics, and the environment, compared to women with lower levels of the chemicals. The study was published online Jan. 28 in PLOS ONE.
More Reading
Medical patients sometimes hear what we say skeptically, but Americans in general will believe any darn thing.