Cindy T. McEvoy, MD, from the Oregon Health & Science University in Portland, and colleagues compared the results of pulmonary function tests (PFTs) among newborns of pregnant smokers randomized to receive daily vitamin C or placebo. Participants included 159 newborns of randomized pregnant smokers (76 vitamin C treated; 83 placebo treated) and 76 newborns of pregnant nonsmokers. Infants were followed through age 1 and PFTs were conducted at age 1.
The researchers found that pulmonary function was improved among newborns of women randomized to vitamin C versus placebo, as measured by ratio of the time to peak tidal expiratory flow to expiratory time and passive respiratory compliance per kilogram. Through age 1, offspring of women randomized to vitamin C had significantly decreased wheezing. No significant between-group differences were seen in the PFT results at age 1 year.
"Vitamin C in pregnant smokers may be an inexpensive and simple approach to decrease the effects of smoking in pregnancy on newborn pulmonary function and respiratory morbidities," the authors write.
One author disclosed financial ties to Pfizer.