HCPLive Network

Acute Hypertriglyceridemia, Insulin Resistance, and Platelet Hyperactivity in PCOS

 
Recent study data suggests that acute, induced hypertriglyceridemia (HTG) increases platelet activation; however, this effect is not attenuated by insulin in women with PCOS as it is in healthy subjects.
 
Myint M. Aye, MRCP, at the Hull York Medical School in the United Kingdom, and colleagues reported their findings at ENDO 2013: The Endocrine Society’s 95th Annual Meeting & Expo in San Francisco on June 18, 2013.
 
According to the researchers, PCOS is commonly associated with metabolic syndrome, postprandial hypertriglyceridemia, insulin resistance (IR), and subsequent cardiovascular risks. IR is associated with platelet dysfunction, which plays a role in atherothrombosis. The authors aimed to evaluate the effects of induced, acute HTG and IR on platelet function in women with PCOS.
 
The study included 13 women with PCOS and 12 healthy women. As expected, the PCOS women were hyperandrogenic and insulin resistant when compared with controls. After an overnight fast, they received a 5 hour saline infusion. At 180 minutes, insulin sensitivity was measured using a hyperinsulinemic euglycemic clamp. Blood samples for platelet studies were collected at hours 2 and 5; platelet activation was measured by fibrinogen binding and P selectin expression in response to the agonist adenosine diphosphate (ADP) and antagonist prostacyclin (PGI2). This process was repeated one week later with a 5 hour infusion of 20% intralipid instead of saline.  


Further Reading
Researchers at Hong Kong University and the Wellcome Trust Sanger Institute have identified a link between the influenza A viruses’ genetic diversity and severity of the infection.
Carol Burke, MD, FACG, FASGE, talks about her phase-3 placebo-controlled trial of Celecoxib in pediatric subjects with familial adenomatous polyposis (FAP) at the 2014 ACG Annual Meeting in Philadelphia, PA.
Carol Burke, MD, FACG, FASGE, discusses pediatric familial adenomatous polyposis (FAP) and colorectal cancer at the 2014 ACG Annual Scientific Meeting in Philadelphia, PA.
The immune system is the new focus of much work on traumatic brain injury (TBI). In a challenge to the paradigm that the blood brain barrier prevents harmful leukocytes from entering the brain, a Texas team tried to neutralize the impact of these cells. Peripheral lymphocytes are activated after TBI. They may then act as potential antigen presenting cells and get into the brain, causing cells there to degenerate.
Black women undergoing in vitro fertilization are only about half as likely as white women to become pregnant, and the racial disparity persists even when donor eggs are used. These findings are being presented at the annual meeting of the American Society for Reproductive Medicine, held from Oct. 18 to 22 in Honolulu.
Hospital conversion to for-profit status is associated with improvements in financial margins, but has no effect on process quality metrics or mortality rates, according to a study published in the Oct. 22/29 issue of the Journal of the American Medical Association
Drinking sugar-sweetened sodas may affect cellular aging by shortening telomere length, according to research published online Oct. 16 in the American Journal of Public Health.
More Reading
Researchers at Hong Kong University and the Wellcome Trust Sanger Institute have identified a link between the influenza A viruses’ genetic diversity and severity of the infection.