Children with Cushing's Syndrome

Children with Cushing’s Syndrome: Primary Pigmented Nodular Adrenocortical Disease Should Always Be Suspected
Journal: Pituitary (October 6, 2010)
Authors: Gonçalves da Silva R, Pinto E, GoldmanS
Purpose: Here the authors “discuss the clinical and molecular findings of two Brazilian patients with ACTH-independent Cushing’s syndrome (CS) due to Primary Pigmented Nodular Adrenocortical Disease (PPNAD) and…show the diagnostic challenge CS represents in childhood.”
Results: “After several clinical and laboratory drawbacks that misled the diagnostic investigation in both patients, the diagnosis of PPNAD was finally established and confirmed through pathology and molecular studies.” The authors stress that “the etiologic diagnosis of endogenous CS in children is a challenge that requires expertise and a multidisciplinary collaboration for its prompt and correct management” and that “although rare, PPNAD should always be considered among the possible etiologies of CS, due to the high prevalence of this disease in this age group.”
http://hcp.lv/h80DkJ