Improvement in Left Ventricular Systolic, Diastolic Performance During Ranolazine Treatment

Improvement in Left Ventricular Systolic and Diastolic Performance During Ranolazine Treatment in Patients with Stable Angina
Journal: Journal of Cardiovascular Pharmacology and Therapeutics (October 5, 2010)
Authors: Figueredo V, Pressman G, Romero-Corral A, et al
Purpose: “By preventing myocyte sodium and calcium overload, ranolazine also have potential beneficial effects on myocardial function.” Because previous research “support[s] this concept,” researchers sought to evaluate “changes in parameters of left ventricular function in stable angina patients treated with oral ranolazine.”
Results: “Global left ventricular function, as assessed by the myocardial performance index, was significantly improved on drug therapy…due to improvement in both diastolic and systolic parameters.” Out of 21 total patients, “17 reported less angina and 8 patients reported an increase in activity level.”
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