Prepared by Laura Ann Granville, MD, Cytopathology Fellow, Deborah Citron, MD, Assistant Professor and Director, Pathology Residency Program, and Rodolfo Laucirica, MD, Associate Professor and Director, Cytopathology Fellowship Program, Baylor College of Medicine, Houston, Tex

A 36-year-old woman presented with general malaise, fever, and fatigue. Physical examination showed marked bilateral cervical lymphadenopathy, which was slightly more prominent on the right side. A complete blood cell count revealed leukocytosis, with mild anemia. A superficial fine-needle aspiration of a lymph node on the right side was performed (Figure 1), and a biopsy was later obtained (Figure 2), confirming the diagnosis.

What’s Your Diagnosis?

Hodgkin’s lymphoma

Rosai-Dorfman disease

Non-Hodgkin’s lymphoma

Metastatic melanoma