HCPLive

Researchers Find Genetic Connection to Rheumatoid Arthritis

Researchers in China have found evidence of genetic links to rheumatoid arthritis (RA) and the related condition ankylosing spondylitis (AS), according to provisional results reported online last Friday in the journal Arthritis Research & Therapy.
 
In a previous study, the researchers found increased expression of the gene TXNDC5 in the synovial tissues of patients with RA. Now they have investigated whether single nucleotide polymorphisms (SNPs), or sections of genetic material where a single letter of the genetic code is frequently mutated, in and near the same gene are linked with development of RA or AS.
 
The researchers looked at 96 SNPs in or near the TXNDC5 gene in 267 patients with RA, 51 patients with AS, and 160 healthy patients. In addition, they looked at four SNPs for 951 RA patients and 898 healthy patients. The results: Nine SNPs were found to be significantly associated with RA, and 16 SNPs were found to be significantly associated with AS.
 
Around the Web
 
Investigating a pathogenic role for TXNDC5 in rheumatoid arthritis (provisional abstract) [Arthritis Research & Therapy] 


Most Popular

Recommended Reading

Treatment with rituximab can significantly reduce rheumatoid arthritis flare up, according to results of a study published in the Journal of Clinical Rheumatology.
With 259 million painkiller prescriptions written in 2012 alone, according to the Centers for Disease Control and Prevention (CDC), one of the most common side effects experienced by patients being treated for chronic pain is opioid-induced constipation (OIC).
Sanjey Gupta, MD, weighs in on the Affordable Care Act and its effect on emergency care.
A new meta-study of bee venom therapy finds considerable risk of anaphylaxis and other reactions, concluding that only experts should offer it to patients.
$vAR$