HCPLive

Researchers Find Genetic Connection to Rheumatoid Arthritis

Researchers in China have found evidence of genetic links to rheumatoid arthritis (RA) and the related condition ankylosing spondylitis (AS), according to provisional results reported online last Friday in the journal Arthritis Research & Therapy.
 
In a previous study, the researchers found increased expression of the gene TXNDC5 in the synovial tissues of patients with RA. Now they have investigated whether single nucleotide polymorphisms (SNPs), or sections of genetic material where a single letter of the genetic code is frequently mutated, in and near the same gene are linked with development of RA or AS.
 
The researchers looked at 96 SNPs in or near the TXNDC5 gene in 267 patients with RA, 51 patients with AS, and 160 healthy patients. In addition, they looked at four SNPs for 951 RA patients and 898 healthy patients. The results: Nine SNPs were found to be significantly associated with RA, and 16 SNPs were found to be significantly associated with AS.
 
Around the Web
 
Investigating a pathogenic role for TXNDC5 in rheumatoid arthritis (provisional abstract) [Arthritis Research & Therapy] 

Most Popular

Recommended Reading

LDL-C was reduced in RA patients who took tocilizumab compared to placebo in a study published in Annals of the Rheumatic Diseases.
Rheumatoid arthritis patients have increased cardiovascular morbidity and mortality, but tofacitinib can reduce these issues, according to research published in Arthritis & Rheumatology.
You can tell a lot about a person by the way they walk, the way they sit, and the way they conduct themselves in general. Recent research has also shown that signs of potential health issues can be seen when watching a person move.
Electronic health records are a valuable source of data that can be mined to help practices with quality improvement performance, according to a study published in Medical Economics.
$vAR$