HCPLive

Atherosclerosis Noted in Pediatric HIV Patients

 
THURSDAY, Dec. 6 (HealthDay News) -- Children and adolescents with HIV have a significantly increased intima-media thickness (IMT), according to a study presented at the European Society of Cardiology's EUROECHO & other Imaging Modalities 2012, held from Dec. 5 to 8 in Athens, Greece.

Talia Sainz Costa, M.D., from the University General Hospital Gregorio Maranon in Madrid, Spain, and colleagues used echocardiography to evaluate carotid IMT in 150 HIV-infected pediatric and adolescent patients and 150 controls. Anthropometric and lipid measures were recorded.

The researchers found that IMT was significantly thicker in HIV patients compared with control subjects (0.434 versus 0.424; P = 0.018). HIV was independently associated with thicker IMT (odds ratio, 2.68) after adjustment for age, sex, body mass index, and smoking status. In subgroup analysis of 34 patients with HIV and 11 controls for whom immune activation markers were determined, frequencies of activated T CD4+ cells were significantly higher among HIV infected patients. Compared to patients with undetectable viral loads or control subjects, treated and viremic patients had the highest frequency of CD4+ and CD8+ activation and senescence.

"HIV research is investigating ways to control the inflammation and immune activation with agents such as probiotics, aspirin, and corticoids. In the meantime clinicians need to focus on ensuring their young patients with HIV take the antiretroviral treatment, take lipid lowering drugs when necessary, and adopt healthier lifestyles," Sainz Costa said in a statement.
 

Press Release
More Information

 
Copyright © 2012 HealthDay. All rights reserved.
 
 

Most Popular

Recommended Reading

Elderly and frail patients whose blood pressure is also being treated need to be carefully treated, suggest findings published in JAMA Internal Medicine.
Cardiac biomarker testing is often used in emergency department visits even when there is no suspected symptom of acute coronary syndrome, according to research from UT Southwestern Medical Center.
Two days after the US Food and Drug Administration announced that testosterone replacement products must now carry warning labels on the risks of heart attack and stroke, 2 researchers presented abstracts of studies indicating that there is no such danger. The studies were publicized by the American College of Cardiology and will be presented in detail at the group's upcoming meeting in San Diego, CA.
In many states the sale of electronic cigarettes is not as regulated as the more traditional method making it an option for many young potential users.
$vAR$