HCPLive

Biomarker May Predict Gestational Diabetes Development

TUESDAY, June 11 (HealthDay News) -- Increased plasma concentrations of soluble (pro)renin receptor during the first trimester of pregnancy may predict the development of gestational diabetes mellitus, according to research published in the June issue of the Journal of Clinical Endocrinology & Metabolism.

Noriyoshi Watanabe, MD, of the Tokyo Women's Medical University, and colleagues conducted a prospective cohort study between 2010 and 2011 involving 716 women who first visited a referral birth center during their first trimester of a singleton pregnancy. None of the women had preexisting diabetes mellitus.

The researchers found that 44 women (6.1 percent) had gestational diabetes mellitus and 672 women (93.9 percent) did not. After multivariate adjustment for baseline characteristics, medical complications, and gestational characteristics, the risk of developing gestational diabetes mellitus for women in the highest versus the lowest quartile of soluble (pro)renin receptor concentration was 2.90.

"We found that increased soluble (pro)renin receptor concentrations in the first trimester were associated with the development of gestational diabetes mellitus later in pregnancy," the authors write. "Further studies will be needed to clarify whether soluble (pro)renin receptor contributes to the pathogenesis of gestational diabetes mellitus."

Abstract
Full Text (subscription or payment may be required)

Copyright © 2013 HealthDay. All rights reserved.

Most Popular

Recommended Reading

While children with HIV may have low levels of a key immune cell, a new study shows that most will recover the cell with proper treatment.
Although the relationship between pain and spatial representation is unclear, a study published in Current Biology took steps in understanding how pain is activated in the brain and raised the possibility of reducing the sensation.
Patients administered minimally invasive surgery (MIS) colon resection procedures instead of open surgery leave the hospital quicker and require less follow up with physicians and fewer medical prescriptions.
Working in an emergency room setting in the United States, in almost all circumstances provides doctors with at least most of the major needs they require to do their jobs on a daily basis. One organization is working to bring those basic needs to hospitals throughout Latin America.
$vAR$