HCPLive

Cadaveric Growth Hormone Does Not Appear to Transmit Alzheimer’s, Parkinson’s Disease

 
cadaveric growth hormone does not transmit Alzheimer's disease or Parkinson's diseaseTUESDAY, Feb. 5 (HealthDay News) -- There seems to be no evidence to support human-to-human transmission of Alzheimer's disease (AD) or Parkinson's disease (PD) via transmission of neurodegenerative disease (ND)-associated proteins (NDAPs) in recipients of cadaveric human growth hormone (c-hGH), according to a study published online Feb. 4 in JAMA Neurology.

Noting the growing evidence of cell-to-cell transmission of NDAPs, David J. Irwin, M.D., from the University of Pennsylvania Perelman School of Medicine in Philadelphia, and colleagues examined evidence for human-to-human transmission of AD, PD, and related NDAPs in 34 routine autopsy subjects (10 non-ND controls and 24 patients with ND) and among recipients of c-hGH in the U.S. National Hormone and Pituitary Program (NHPP) cohort.

In ND and control patients, the researchers identified mild amounts of pathological tau, amyloid-β, and α-synuclein deposits in the adeno/neurohypophysis. Among U.S. NHPP c-hGH recipients, there were no cases of AD or PD; three deaths were attributed to amyotrophic lateral sclerosis.

"In this unique in vivo model of human-to-human transmission, we found no evidence to support concerns that NDAPs underlying AD and PD transmit disease in humans despite evidence of their cell-to-cell transmission in model systems of these disorders," the authors write. "Further monitoring is required to confirm these conclusions."

Two authors disclosed financial ties to the pharmaceutical industry.
 

Abstract
Full Text (subscription or payment may be required)


Copyright © 2013 HealthDay. All rights reserved.
 
 

Most Popular

Recommended Reading

The US had been found to have a higher percentage of opioid use than in any other country.
While children with HIV may have low levels of a key immune cell, a new study shows that most will recover the cell with proper treatment.
Although the relationship between pain and spatial representation is unclear, a study published in Current Biology took steps in understanding how pain is activated in the brain and raised the possibility of reducing the sensation.
Patients administered minimally invasive surgery (MIS) colon resection procedures instead of open surgery leave the hospital quicker and require less follow up with physicians and fewer medical prescriptions.
$vAR$