HCPLive

Low Muscle Strength, Cardiorespiratory Fitness Worsens Insulin Resistance in Teens

THURSDAY, April 25 (HealthDay News) -- Lower levels of abdominal muscle strength and cardiorespiratory fitness (CRF) in youth are independently associated with adverse levels of fasting insulin, insulin sensitivity, and β-cell function in young adulthood, according to a study published online April 11 in Diabetes Care.

Anders Grøntved, MPH, from the University of Southern Denmark, in Odense, and colleagues analyzed data from 317 youth prospectively followed for 12 years. The participants had measurements taken in youth for maximal voluntary contractions during isometric back extension and abdominal flexion using a strain-gauge dynamometer, while CRF was obtained from a maximal cycle ergometer test. Additionally, fasting serum insulin and glucose were measured during youth and in young adulthood.

The researchers found that for each one standard deviation difference in isometric muscle strength (0.16 N/kg) in youth, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), and HOMA of β-cell function (HOMA-B) in young adulthood changed by −11.3, −12.2, and −8.9 percent, respectively, in young adulthood. These findings were after adjusting for CRF, personal lifestyle, and demographic factors. Results were consistent even with additional adjustment for general or abdominal adiposity in youth. There was an additive combined association between muscle strength and CRF with fasting insulin, HOMA-IR, and HOMA-B. Adolescents in the highest sex-specific tertile for both isometric muscle strength and CRF had the lowest levels of these glucose metabolism outcomes.

"Increasing muscle strength and CRF should be targets in youth primordial prevention strategies of insulin resistance and β-cell dysfunction," the authors write.

Abstract
Full Text (subscription or payment may be required)

Copyright © 2013 HealthDay. All rights reserved.

Most Popular

Recommended Reading

Multicenter phase II study will also evaluate pharmacokinetics of omega-3 carboxylic acids and omega-3-acid ethyl esters administered to patients with varying degrees of EPI.
Study results show that treatment with atorvastatin lowers LDL-cholesterol levels and reduces the volume of noncalcified and high-risk plaques in HIV-infected patients with subclinical atherosclerosis.
For men with recent acute myocardial infarction, a home-based walking program is associated with a reduction in reported erectile dysfunction, according to a study published in the March 1 issue of The American Journal of Cardiology.
The beagle may have reigned supreme at the Westminster Kennel Club’s Dog Show earlier this month, but if the event were a popularity contest, a very different breed would have taken home the top prize.
$vAR$