HCPLive

Research Points to Promising Target for Irritable Bowel Disorder Therapies

 
Researchers at Wake Forest Baptist Medical Center and colleagues have identified a potential target for more effective therapies for irritable bowel disease (IBD) – a subset of human bone marrow stromal cells (HBMSC) that can thrive in the intestine and potentially help restore tissue within the intestine.
 
According to a news release from Wake Forest Baptist Medical Center, senior researcher Graca Almeida-Porada, MD, PhD, professor of regenerative medicine at Wake Forest Baptist's Institute for Regenerative Medicine, and colleagues “used cell markers to identify a population of stem cells in human bone marrow with the highest potential to migrate to the intestine and thrive.” The cells express high levels of Ephrin type B receptor 2 (EphB2), which is “involved in tissue repair and wound closure.”
 
Almeida-Porada is quoted in the release as saying that his team “identified two populations of human cells that migrate to the intestine‑‑one involved in blood vessel formation and the other that can replenish intestinal cells and modulates inflammation,” and hopes that “a mixture of these cells could be used as an injectable therapy to treat IBD.”
 
For the study, the researchers transplanted the HBMSCs into fetal sheep. They reported that “most of the transplanted cells were positioned in the crypt area, replenishing the stem cells in the intestine” at 75 days post-transplantation.
 
Almeida-Porada said that this study could be significant because although previous animal studies have “shown that the transplantation of bone-marrow-derived cells can contribute to the regeneration of the gastrointestinal tract in IBD,” the studies involved only small numbers of successfully transplanted cells.
 
He said the goal of this study was “to identify populations of cells that naturally migrate to the intestine and have the intrinsic ability to restore tissue health.” As the current study looked only at the cells’ ability to migrate to and survive in a healthy intestine, future studies will need to investigate cells’ viability in an inflamed intestine.
 
The study results were reported in “EphB2 Isolates a Human Marrow Stromal Cell Subpopulation with Enhanced Ability to Contribute to the Resident Intestinal Cellular Pool,” published in The FASEB Journal (the Journal of the Federation of American Societies for Experimental Biology). The authors described these results as identifying “a marker for isolating and culturing an expandable subpopulation” of HBMSCs with “enhanced intestinal homing and contribution to the [intestinal stem cell] region.”
 

Most Popular

Recommended Reading

Bariatric surgery has been shown to reduce the long-term risk of diabetes-associated vascular disease in obese patients. According to study results presented at ENDO 2015, bariatric surgery reduced the risk of developing macrovascular events by 20% and reduced the risk of microvascular events by 50%.
Analysis indicates that current measures may underestimate predicted adult height in obese girls, and overestimate predicted adult height in obese boys.
We need to be careful that the laying on of hands is not replaced by the tapping of thumbs. If it is, we will have to grapple with the consequences.
In overweight and obese individuals without diabetes, liraglutide 3.0 mg as an adjunct to diet and exercise was associated with greater reductions in fasting and postprandial glucose compared with diet and exercise alone.
$vAR$