Nearly two years after Eli Lilly and Co. halted a pair of clinical trials on its gamma-secretase inhibitor for Alzheimer’s disease following the candidate’s failure to demonstrate results superior to placebo, the drug maker has terminated a phase 2 study of its investigational beta-secretase (BACE) inhibitor for the same neurological condition — this time citing liver abnormalities.
Hypertriglyceridemia combined with insulin resistance may lead to increased platelet activation in women with polycystic ovary syndrome (PCOS).
About a fifth of patients who have received a spinal injection of fungus-contaminated methylprednisolone but have not sought medical care are likely to be infected.
The eating behaviors of preschool-aged children may be tied to measures of future cardiovascular risk.
Following reports of invasive meningococcal disease (IMD) among men who have sex with men (MSM), the New York City (NYC) Department of Health and Mental Hygiene (DOHMH) has recommended that MSM who have engaged in intimate contact with another man should undergo vaccination.
Study shows that 12 weeks of vitamin D supplementation in obese adolescents does not affect cardiometabolic risk factors.
At ENDO 2013, an expert panel discussed the consensus statement on the evaluation and treatment of hypertriglyceridemia and the evidence supporting the recommendations.
Study results show improvements in body composition, intrahepatic lipids, and cardiovascular risk markers in obese men treated with growth hormone for six months compared with placebo.
In older adults, concomitant administration of clarithromycin, or erythromycin, with a statin that is metabolized by cytochrome P450 isoenzyme 3A4 (CYP3A4) increases the risk for statin toxicity.
Functionally impaired variants in the COQ2 gene, which encodes the enzyme parahydroxybenzoate-polyprenyl transferase, have been identified in multiplex families with multiple-system atrophy and in patients with sporadic disease.