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The Net Guide: COPD

MDNG Primary Care, June 2010, Volume 12, Issue 6

We searched the Internet for COPD resources so you don't have to.

//The Educated Patient™

The Global Initiative for COPD: Patient Guide

This PDF describes how lungs function in healthy individuals and contrasts that with illustrated content showing what happens to the lungs of a patient with COPD. The guide goes on to review the symptoms associated with COPD and explains how lung damage can affect quality of life. Information in “What you and your family can do to help slow the damage to your lungs” is divided into five sections, in numerical order, and focuses on quitting smoking, maintaining the correct medication regimen, the benefits of exercise, and more. The site also provides information about planning ahead if you will be traveling in order to keep COPD-related problems at bay.

Link Code:a12621


//Medical Websites

Clinical Identification of Phenotypes in COPD (CLIP-COPD)

The phenotype estimation model available at this website allows physicians to enter data from a patient’s clinical history, physical exam, functional data, and chest radiography data. The site then provides physicians with the COPD phenotype that best fits that patient. This information can be used in the clinical setting to further tailor treatment options that are specific for that patient. The estimation model is derived from “Identification of a Predominant COPD Phenotype in Clinical Practice,” an article published in the March 2008 issue of Respiratory Medicine (http://bit.ly/bXrPwK).

Link Code:a12611

COPD Foundation — Medical Professionals

The COPD Foundation gathers guidelines for diagnosis and management of COPD from the American Thoracic Society, European Respiratory Society, Global Initiative for Chronic Obstructive Lung Disease, and the American College of Physicians into one conveniently accessible place. The COPD Foundation has also developed “a concise Pocket Consultant with the most pertinent information about diagnosing and managing COPD,” which can be found by clicking on “COPD Guidelines” and following through to the “Publications” page. The “Testing and Diagnosis” section provides information about spirometry, patterns of COPD management in the primary care setting, and the link between comorbidities and COPD management.

Link Code:a12612


Proteomic Expression Profiling of Haemophilus Influenzae Grown in Pooled Human Sputum from Adults with Chronic Obstructive Pulmonary Disease Reveal Antioxidant and Stress Responses

Journal:BMC Microbiology (June 2010)

Authors:Qu J, Lesse A, Brauer A, et al.

Purpose:To explore the conditions under which H. influenzae survives within the airways of adults with COPD.

Results:The 1,402 proteins included eight anti-oxidant and five stress-related proteins, suggesting that expression of antioxidant activity and stress responses are important for survival in the airways. The researchers conclude: “These observations suggest that H. influenzae adapts to the oxidative and nutritionally limited conditions of the airways in adults with chronic obstructive pulmonary disease by increasing expression of molecules necessary for survival in these conditions.”

Link Code:a12651

//Clinical Trials

Coping Skills for Patients with Chronic Obstructive Pulmonary Disease (COPD) and their Caregivers

Study Type:Interventional

Age/Gender Requirements:21 years+ (male/female)

Sponsor:Duke University

Purpose:To examine “the effects of a telephone-based, caregiver assisted, coping skills training (CST) program” in patients and caregivers to determine if it helps patients and loved ones deal more effectively with the stress of the disease.

Link Code:a12661

Randomized Trial of Physical Activity Selfmanagement Intervention for Patients with COPD

Study Type:Interventional

Age/Gender Requirements:45 years+ (male/female)

Sponsor:National Heart, Lung, and Blood Institute

Purpose:To determine if a novel physical activity self-management (PASM) program will result in “clinically and statistically significant improvements in functional performance (ie, Chronic Respiratory Questionnaire [CRQ] dyspnea domain and 6-minute walk)”compared to the outcomes obtained by usual care (UC). The study will also address the cost-effectiveness of PASM compared to UC.

Link Code:a12662

//Online CME

COPD — Enhancing Recognition and Improving Outcomes

Credits: 1.00

Fee: None

Expires: July 31, 2011

Multimedia: Audio/Video

Originally presented as a live webcast at the NACE Emerging Challenges in Primary Care Series: Update 2009, this activity is designed to provide physicians with the knowledge and tools to recognize cases of COPD earlier, a step that is aimed at improving care and treatment outcomes of patients. The program also discusses the diagnosis of COPD and the impact that lifestyle modification can have on COPD outcomes.

Link Code:a12631

Recognition and Management of COPD

Credits: 1.00

Fee: None

Expires: September 21, 2010

Multimedia: None

This activity is designed around the case study of a 56-year-old woman who presents with increased breathiness and a cough that has increased in frequency over the past week. The program guides participants through the patient’s introduction and history, provides the chance to order tests, explains the results, and discusses possible treatment options that are now available. The interactive design of the program allows physicians to increase their knowledge while working in a virtual practice setting.

Link Code:a12632

From the HCPLive Network

Chronic Care Focus: Diagnosis and Treatment of COPD in Health Systems

This review article notes that “both chronic and acute COPD need to be differentiated from other similar respiratory diseases at diagnosis with the proper tools,” and that “health systems need to evaluate current regimens set aside for COPD alongside regimens for treating other respiratory diseases to ensure that overlaps can be made to avoid high cost.”


P h a r m a F o c u s

Ipratropium (Atrovent)


Inhaled albuterol/Salbutamol and Ipratropium Bromide and their Combination in the Treatment of Chronic Obstructive Pulmonary Disease

Journal: Expert Opinion on Drug Metabolism and Toxicology (March 2010)

Authors: Gordon J, Panos R

Purpose: To examine the efficacy of combined albuterol-ipratropium therapy for the treatment of stable COPD in comparison to more recently developed treatments.

Results: Although the combination was an innovative treatment at the time of its approval, and it does provide better improvement in airflow than either treatment alone. “The recent development and approval of longer acting and more potent agonists, anticholinergics and newer combination treatments have surpassed many of the advantages of combined albuterol-ipratropium for the treatment of patients with stable COPD.”

Link Code:a12652

The Educated Patient™

eMedicineHealth: Atrovent

Patients can visit this website to find reliable answers to frequently asked questions about the use of Atrovent, including: “What are the possible side effects of ipratropium inhalation?” “What is the most important information I should know about ipratropium inhalation?” “What should I discuss with my healthcare provider before using ipratropium inhalation?” “How should I use ipratropium inhalation?” and “What happens if I miss a dose?”

Link Code: a126210

Clinical Trials

Sensitivity of New Exercise Tests in Chronic Obstructive Pulmonary Disease

Study Type: Interventional

Age/Gender Requirements: 50 years+ (male/female)

Sponsor: Laval University

Purpose: This trial is designed to “develop simple exercise tests to assess the effects of pharmacological and rehabilitation interventions on exertional dyspnea in the primary care setting.” Patients will complete a total of four exercise tests: two 3-minute constant rate step tests and two 3-min constant rate shuttle walks. Each test will be preceded by the nebulization of either a placebo or 500μg of ipratropium bromide (Atrovent).

Link Code:a126610