Net Guide: Complex Regional Pain Syndrome

Pain Management, June 2010, Volume 3, Issue 4

A collection of links and resources from across the web focused on one specific condition. These resource range from useful websites to clinical trials.

(Type the link codes into our search functions to visit the featured sites)

Stop Pain: Complex Regional Pain Syndrome (CRPS)

This site covers all the bases for patients who need to know about complex regional pain syndrome. Visitors can read up on who gets the syndrome, symptoms, and treatment options. Under the “What Is Happening in My Body to Cause CRPS?” section, readers can learn about sympathetically maintained pain and the role it may play in CRPS. Or, they can simply open up the pop-up interactive flash module, sit back, and listen to the program, which covers all of these topics.

Link Code: pm34302

Reflex Sympathetic Dystrophy Syndrome Association

Direct your patients here to receive reliable information from one of the oldest associations dedicated to complex regional pain syndrome. Patients can read about how CRPS is diagnosed, as well as common symptoms. The site maintains updated collections of recent news, medical articles, research, and events for those who wish to become a part of the association or participate in an event. The website is “designed to give patients, family members, and healthcare professionals the most up-to-date information on treatment, legislation, support groups, research, fundraising, and patient stories.”

Link Code: pm34303

//Medical Websites Complex Regional Pain Syndrome: Treatment Guidelines

Take a look at the guidelines for complex regional pain syndrome featured at the Reflex Sympathetic Dystrophy Syndrome Association’s website. The new edition of the guideline was edited by R. Norman Harden, MD, director, Center for Pain Studies, Addison Chair, Rehabilitation Institute of Chicago. The site features the full-text guideline, from the table of contents to interventional therapies. The appendices on treatment algorithm, pharmacotherapy guide, and psychological intervention are

also included. A gallery of 16 photos accompanies the guideline as well.

Link Code: pm3414

//Online CME Module 5: Complex Regional Pain Syndromes

Credits: 1.00

Fee: $30 (non-members), None


Expires: March 31, 2011

Multimedia: None

This activity is the fifth module in a series of CME activities under the palliative care umbrella. At the conclusion of this module, “participants should be able to understand the symptoms of Complex Regional Pain Syndromes (CRPS); distinguish CRPS1 from CRPS2; and discuss the treatment algorithm for CRPS.”

Link Code: pm3435

//eAbstracts Validation of Proposed Diagnostic Criteria (the “Budapest Criteria”) for Complex Regional Pain Syndrome

Journal: Pain (April 20)

Authors: Harden R, Bruehl S,

Perez R, et al.

Purpose: “This validation study compared current IASP diagnostic criteria for CRPS to proposed new diagnostic criteria (the “Budapest Criteria”) regarding diagnostic accuracy.”

Results: “Discriminating between diagnostic groups based on presence of signs or symptoms meeting IASP criteria showed high diagnostic sensitivity (1.00), but poor specificity (0.41), replicating prior work. In comparison, the Budapest clinical criteria

retained the exceptional sensitivity of the IASP criteria (0.99), but greatly improved upon the specificity (0.68).” The “inclusion of four distinct CRPS components in the Budapest Criteria contributed to enhanced specificity.”

Link Code: pm34591

Familial Occurrence of Complex Regional Pain Syndrome

Journal: Canadian Journal of Neurological Sciences (May 2010)

Authors: Shirani P, Jawaid A,

Moretti P, et al.

Purpose: To further study the etiology of complex regional pain syndrome (CRPS) and evaluate the idea that “different environmental and genetic factors” may contribute

to CRPS.

Results: The team “reviewed the clinical data from a cohort of 69 patients with CRPS.” According to the data, “CRPS can be familial” and “may have a genetic basis in some

families.” The researchers concluded that “larger studies will be needed to ascertain clearer patterns of inheritance.”

Link Code: pm34592

Wherever Is My Arm? Impaired Upper Limb Position Accuracy in Complex Regional Pain Syndrome

Journal: Pain (June 2010)

Authors: Lewis J, Kersten P, McPherson K, et al.

Purpose: Researchers sought to “determine the degree to which experimental data supported the reported difficulty in limb position sense” for patients with complex regional pain syndrome.

Results: Results demonstrated evidence “of bilateral arm positioning impairments in unilateral arm CRPS,” which “suggests that central mechanisms are involved.” The team suggested cortical reorganization “in regions associated with the body” as one explanation.

Link Code: pm34593

//Clinical Trials Safety and Efficacy Study of Ethosuximide for the Treatment of Complex Regional

Pain Syndrome (CRPS)

Study Type: Interventional

Age/Gender Requirements: 18 years+ (male/female)

Sponsor: McGill University Health Center

Purpose: Researchers are looking to “evaluate the efficacy and safety of ethosuximide in search of much-needed adjunctive therapy to relieve the pain and suffering associated with CRPS.”

Link Code: pm3468

P h a r m a F o c u s

Lyrica (Pregabalin)

Clinical Trials

Pregabalin vs Placebo as an Add-on for Complex Regional Pain Syndrome of the Upper Limb Managed by Stellate Ganglion Block

Study Type: Interventional

Age/Gender Requirements: 18-65 years (male/female)

Sponsor: Hamilton Health Sciences

Purpose: “The purpose of this study is to assess the efficacy of pregabalin

in patients with complex regional pain syndrome Type I and to determine

whether it provides clinically significant pain relief and whether it improves

functioning of the upper limb.”

Link Code: pm3469