Trial Initiated to Measure Efficacy of T-Cell Therapy in Secondary Progressive MS


Opexa Therapeutics is initiating a phase IIb trial of a novel therapy that targets T-cells in patients with secondary progressive multiple sclerosis.

This article was originally published on the Specialty Pharmacy Times website.

On May 13, 2014, biotechnology company Opexa Therapeutics announced initiation of the Abili-T phase IIb trial evaluating the efficacy of a T-cell immunotherapy option Tcelna (imilecleucel-T) for treatment of patients with secondary progressive multiple sclerosis.

According to, the double-blind, placebo-controlled, 180-patient trial will evaluate imilecleucel-T over a period of 2 years. During that time, investigators will evaluate the primary outcome of brain atrophy as measured by MRI measures and the secondary outcome of disease progression status.

In a press release, Chief Executive Officer of Opexa Neil K. Warma stated, “Interest from physicians and patients to participate in the study was high, underscoring the need for innovative treatments for Secondary Progressive MS, an area of high unmet medical need.”

Although many treatments are available for patients with relapsing forms of MS, treatment of progressive forms of MS are currently limited to symptom management.

The 2-year study will be conducted at 35 clinical centers across the United States and Canada. Patients will receive 5 subcutaneous injections of imilecleucel-T over a 24-week period at a dose of 30 to 45 million cells per 2-mL injection.

Each 24-week course of therapy will be administered twice yearly. Results are expected in December 2015, although data collection and processing may delay publication of results until 2016.

Click here to access the full-text version of this article on the Specialty Pharmacy Times website.

Recent Videos
Getting Black Men Involved in Their Health Care, Clinical Research
Patient Involvement in Advanced HF Treatment, with Ashley Malliett, DMSc, MPAS, PA-C
Aaron Henry, PA-C, MSHS: Regaining Black Male Patient Trust in the Doctor's Office
How to Adequately Screen for and Treat Cognitive Decline in Primary Care
Tailoring Chest Pain Diagnostics to Patients, with Kyle Fortman, PA-C, MBA
James R. Kilgore, DMSc, PhD, PA-C: Cognitive Decline Diagnostics
Solutions to Prevent Climate Change-Related Illness, with Janelle Bludhorn, PA-C
Kyle Fortman, PA-C, MBA: Troponin and Heart Injury Risk Screening Recommendations
What Should the American Academy of Physician Associates Focus on in 2025?
The Rising Rate of Heat-Related Illness, with Janelle Bludhorn, PA-C
© 2024 MJH Life Sciences

All rights reserved.