May 17th 2024
The smartphone app demonstrated higher accuracy, sensitivity, and specificity in patients with severe anemia than those with moderate anemia.
Retrospective data suggest the off-label use of IVIg could be helpful in the management of severe autoimmune hemolytic anemia.
May 16th 2024
Liposomal iron achieves a partial correction of transferrin saturation, with no significant effect on iron storage and hemoglobin, in patients with NDD-CKD.
May 15th 2024
Automated anemia detection from fundus images may benefit patients undergoing routine retinal imaging.
Announced on May 15, 2024, the IND application supports a phase 1/2 study of CID among adults with chronic ITP.
Hematology Month in Review: April 2024
Our April month in review for hematology breaks down the latest updates to the pipeline, mortality risk in people with sickle cell disease, and our newest multimedia offerings.
Recombinant ADAMTS13 Prophylaxis Effective Approach for Congenital TTP
An interim analysis of a phase 3 trial displays the effectiveness of prophylaxis with recombinant ADAMTS13, achieving approximately 100% of normal ADAMTS13 levels.
Presence of Anemia Negatively Impacts Long-Term Prognosis in HFmrEF
Anemia and iron deficiency are prevalent in heart failure with mildly reduced ejection fraction and may worsen mortality and rehospitalization outcomes.
Intravenous Iron Boosts Hemoglobin Levels in Children with Anemia, IBD
Treatment with intravenous iron therapy proves more efficacious than oral or no iron therapy in improving hemoglobin in pediatric patients admitted with IBD and IDA.
Current Diagnostics May Misclassify Suspected Heparin-Induced Thrombocytopenia
When the current recommended diagnostic algorithm was used in clinical practice, antibody testing was required in half of patients with suspected HIT.
Alternate-Day Iron May Be More Effective for Patients with Anemia, Diabetes
Oral iron supplements did not significantly differ in increasing hemoglobin and ferritin levels, but the every-other-day oral iron proved more effective than daily use.
Clinical Quiz: Gastrointestinal Evaluation of Iron Deficiency Anemia
This clinical quiz will test your knowledge of iron deficiency anemia, focused on the gastrointestinal evaluation of anemia based on recommendations from the AGA's 2020 guidelines.
Hematology Month in Review: March 2024
Our March 2024 month-in-review in hematology features updates to the anemia pipeline, the latest research in sickle cell disease, and the role of SGLT2 inhibition on hematologic outcomes.
Intravenous Iron Increases Hemoglobin in Heart Failure Treated with SGLT2 Inhibition
Iron-deficient patients on an SGLT2 inhibitor at baseline experienced greater increases in hemoglobin levels with ferric derisomaltose compared with those not taking one.
FDA Approves Vadadustat (Vafseo) Tablets for Anemia Due to CKD in Adult Patients on Dialysis
Vadadustat tablets are now approved for the treatment of anemia due to CKD in adults who have been receiving dialysis for ≥ 3 months.
Allogenic HSCT May Improve Sickle Cell Disease-Related Organ Dysfunction
A new analysis summarized evidence on the effects of allogeneic HSCT on SCD-related organ dysfunction in pediatric and adult patients with SCD.
Vadadustat Response Influenced by Patient Background in Anemia from CKD
A posthoc analysis of two phase 3 trials identified multiple independent factors associated with better response to vadadustat in patients with anemia.
Hemoglobin Levels Predict Renal Outcomes in Diabetic Kidney Disease
A study in China identified a negative and non-linear relationship between hemoglobin levels and a renal composite end point in patients with DKD.
RET-He Levels Detect Iron Deficiency in Acute Decompensated Heart Failure
Measurement of reticulocyte hemoglobin equivalent is cost-effective and could be a useful marker of iron deficiency in acute decompensated heart failure.
Iron Deficiency Linked to Poor Outcomes in Kidney Transplant Recipients
Iron deficiency, independent of anemia, may be a potentially modifiable target to improve patient-reported outcomes after kidney transplantation.
Anemia Exhibits Limited Association with Early Childhood Development
A cross-sectional analysis of nine low- and middle-income countries revealed few statistically significant associations between anemia and early childhood development.
Iptacopan Promotes Anemia Resolution in Paroxysmal Nocturnal Hemoglobinuria
Iptacopan monotherapy improved hematologic outcomes in both anti-C5–treated patients with persistent anemia and those not treated with complement inhibitors across two phase 3 trials.
Iron Deficiency Prevalent, Linked to Adverse Outcomes in Patients with HFrEF
Iron deficiency marks more than a comorbidity in heart failure, with adverse manifestations, including anemia and a higher risk of mortality, influencing the clinical trajectory of patients with HFrEF.
SGLT2 Inhibitor Use Lowers Anemia Risk in Patients with Diabetes, CKD
Initiation of SGLT2 inhibitors reduced the risk of composite anemia outcomes, compared with GLP-1 RA, among patients with type 2 diabetes and CKD.
Quality Initiative Enhances Iron Deficiency Screening, Treatment in Heart Failure
Introduction of curated materials to assist clinicians was linked to better rates of screening and treatment of iron deficiency anemia among patients with heart failure.
Iron Deficiency Prevalent in Older Patients Admitted to Geriatric Units
More than half of older patients admitted to geriatric units in France had iron deficiency, including patients without anemia.
Iron Isomaltoside Comparable to Iron Sucrose in Anemia Treatment
A meta-analysis of four RCTs found Iron isomaltoside ferumoxytol is both effective and safe to treat iron deficiency anemia.
Voxelotor Improves Cerebral Hemodynamic Parameters in Pediatric Sickle Cell Disease
Voxelotor decreases oxygen extraction fraction and cerebral blood flow towards levels observed in healthy children.
Children with Sickle Cell Disease Show No Alarming Trends After Opioid Use
No concerning patterns of long-term or increasing opioid use were observed within 3 years after first opioid prescription in opioid-naive children with SCD.
Hearing Loss Prevalence High in Children, Adults with Sickle Cell Disease
Hearing loss was more prevalent among children and adults with sickle cell disease and its traits compared to matched controls with normal hemoglobin.
Clinical Pain Screening Proves Feasible in Pediatric Sickle Cell Disease
Over the study period, pain screening procedures were integrated within routine clinical visits and providers’ workflow in sickle cell disease care.
Iron Deficiency Associated with Hearing Loss Risk in Adolescents
Microalbuminuria and low body iron levels displayed a significant association with pediatric hearing loss independently.
FDA Approves Iloprost Injection for Treatment of Severe Frostbite
The approval provides patients with the first-ever treatment option for severe frostbite to prevent the amputation of fingers or toes.
Mitapivat Sustains Reduction in Iron Burden in Pyruvate Kinase Deficiency
Mitapivat treatment was linked to long-term improvements in key markers of iron homeostasis and erythropoiesis in an analysis of the phase 3 ACTIVATE trial.
Iron Deficiency More Common in Preterm Infants Not Fed with Breast Milk
Non-breast milk-fed infants received more iron on average each day than breast-milk-fed infants, but experienced a higher rate of iron deficiency.