June 10th 2024
A higher serum ferritin threshold could lead to better diagnosis and treatment of more women with iron deficiency.
June 7th 2024
Knowledge, attitudes, and practices remain relevant for disease management among patients with anemia.
June 6th 2024
Daprodustat 25-30 mg was linked to the most significant rise in serum hemoglobin and reduced serum ferritin levels.
June 4th 2024
Our May 2024 month-in-review for hematology focuses on important FDA updates, new anemia data from ERA 2024, and the latest imaging modalities.
May 31st 2024
Diagnostic tests for anemia etiology are infrequently ordered, leading to a significant majority of patients with CKD receiving inadequate treatment.
Mortality Risk Unchanged by Iron Dose in Hemodialysis Patients with Cancer
Iron administration did not increase the mortality risk of hemodialysis patients with cancer, but the safety of increasing ESA doses was not confirmed.
Anemia Increases Risk of End-Stage Kidney Disease in IgA Nephropathy
An analysis of more than 800 IgAN patients treated from 2002-2021 provides an overview of factors associated with anemia as well as its impact on prognosis.
SGLT2 Inhibitors Can Improve Anemia in Patients with CKD
Data from ERA 24 builds on previous research examining the effect of SGLT2 inhibitors on hemoglobin levels among patients with chronic kidney disease.
ROXSTAR Registry Offers Insight into Effects of Roxadustat in Real-World Settings
Study finds roxadustat effectively treats anemia in both dialysis-dependent and non-dialysis-dependent CKD patients.
Smartphone App Accurate in Anemia Detection from Conjunctival Images
The smartphone app demonstrated higher accuracy, sensitivity, and specificity in patients with severe anemia than those with moderate anemia.
Intravenous Immunoglobulin May Benefit Severe Autoimmune Hemolytic Anemia
Retrospective data suggest the off-label use of IVIg could be helpful in the management of severe autoimmune hemolytic anemia.
Oral Liposomal Iron Helps Correct Iron Deficiency in Non-Dialysis CKD
Liposomal iron achieves a partial correction of transferrin saturation, with no significant effect on iron storage and hemoglobin, in patients with NDD-CKD.
Artificial Intelligence Algorithms Detect Anemia from Fundus Images
Automated anemia detection from fundus images may benefit patients undergoing routine retinal imaging.
FDA Clears IND Application for CID-103 in Immune Thrombocytopenia
Announced on May 15, 2024, the IND application supports a phase 1/2 study of CID among adults with chronic ITP.
Hematology Month in Review: April 2024
Our April month in review for hematology breaks down the latest updates to the pipeline, mortality risk in people with sickle cell disease, and our newest multimedia offerings.
Recombinant ADAMTS13 Prophylaxis Effective Approach for Congenital TTP
An interim analysis of a phase 3 trial displays the effectiveness of prophylaxis with recombinant ADAMTS13, achieving approximately 100% of normal ADAMTS13 levels.
Presence of Anemia Negatively Impacts Long-Term Prognosis in HFmrEF
Anemia and iron deficiency are prevalent in heart failure with mildly reduced ejection fraction and may worsen mortality and rehospitalization outcomes.
Intravenous Iron Boosts Hemoglobin Levels in Children with Anemia, IBD
Treatment with intravenous iron therapy proves more efficacious than oral or no iron therapy in improving hemoglobin in pediatric patients admitted with IBD and IDA.
Current Diagnostics May Misclassify Suspected Heparin-Induced Thrombocytopenia
When the current recommended diagnostic algorithm was used in clinical practice, antibody testing was required in half of patients with suspected HIT.
Alternate-Day Iron May Be More Effective for Patients with Anemia, Diabetes
Oral iron supplements did not significantly differ in increasing hemoglobin and ferritin levels, but the every-other-day oral iron proved more effective than daily use.
Clinical Quiz: Gastrointestinal Evaluation of Iron Deficiency Anemia
This clinical quiz will test your knowledge of iron deficiency anemia, focused on the gastrointestinal evaluation of anemia based on recommendations from the AGA's 2020 guidelines.
Hematology Month in Review: March 2024
Our March 2024 month-in-review in hematology features updates to the anemia pipeline, the latest research in sickle cell disease, and the role of SGLT2 inhibition on hematologic outcomes.
Intravenous Iron Increases Hemoglobin in Heart Failure Treated with SGLT2 Inhibition
Iron-deficient patients on an SGLT2 inhibitor at baseline experienced greater increases in hemoglobin levels with ferric derisomaltose compared with those not taking one.
FDA Approves Vadadustat (Vafseo) Tablets for Anemia Due to CKD in Adult Patients on Dialysis
Vadadustat tablets are now approved for the treatment of anemia due to CKD in adults who have been receiving dialysis for ≥ 3 months.
Allogenic HSCT May Improve Sickle Cell Disease-Related Organ Dysfunction
A new analysis summarized evidence on the effects of allogeneic HSCT on SCD-related organ dysfunction in pediatric and adult patients with SCD.
Vadadustat Response Influenced by Patient Background in Anemia from CKD
A posthoc analysis of two phase 3 trials identified multiple independent factors associated with better response to vadadustat in patients with anemia.
Hemoglobin Levels Predict Renal Outcomes in Diabetic Kidney Disease
A study in China identified a negative and non-linear relationship between hemoglobin levels and a renal composite end point in patients with DKD.
RET-He Levels Detect Iron Deficiency in Acute Decompensated Heart Failure
Measurement of reticulocyte hemoglobin equivalent is cost-effective and could be a useful marker of iron deficiency in acute decompensated heart failure.
Iron Deficiency Linked to Poor Outcomes in Kidney Transplant Recipients
Iron deficiency, independent of anemia, may be a potentially modifiable target to improve patient-reported outcomes after kidney transplantation.
Anemia Exhibits Limited Association with Early Childhood Development
A cross-sectional analysis of nine low- and middle-income countries revealed few statistically significant associations between anemia and early childhood development.
Iptacopan Promotes Anemia Resolution in Paroxysmal Nocturnal Hemoglobinuria
Iptacopan monotherapy improved hematologic outcomes in both anti-C5–treated patients with persistent anemia and those not treated with complement inhibitors across two phase 3 trials.
Iron Deficiency Prevalent, Linked to Adverse Outcomes in Patients with HFrEF
Iron deficiency marks more than a comorbidity in heart failure, with adverse manifestations, including anemia and a higher risk of mortality, influencing the clinical trajectory of patients with HFrEF.
SGLT2 Inhibitor Use Lowers Anemia Risk in Patients with Diabetes, CKD
Initiation of SGLT2 inhibitors reduced the risk of composite anemia outcomes, compared with GLP-1 RA, among patients with type 2 diabetes and CKD.
Quality Initiative Enhances Iron Deficiency Screening, Treatment in Heart Failure
Introduction of curated materials to assist clinicians was linked to better rates of screening and treatment of iron deficiency anemia among patients with heart failure.
Iron Deficiency Prevalent in Older Patients Admitted to Geriatric Units
More than half of older patients admitted to geriatric units in France had iron deficiency, including patients without anemia.