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Nutritional Supplements May Accelerate Wound Healing in Diabetic Foot Ulcers

Diabetic foot ulcer (DFU)—which is usually of vascular or neuropathic origin following trauma, pressure, or burn—is costly to treat and can cause personal pain and suffering for affected patients. In addition, the ulcers are notoriously difficult to cure, and compared to the general patient population, diabetics usually experience delayed wound healing — so much so that amputation is inevitable for about 2 percent of diabetes patients.

While researchers are aware that each patient’s nutritional status and underlying diabetic complications and comorbidities can delay healing, they have been unable to locate interventions that can improve a patient’s prognosis.

Researchers from the Department of Surgery at the University of Nevada studied the issue extensively by developing an overview of how DFUs are currently treated. As their findings confirmed the current unsatisfactory state of affairs, the investigators then studied the effectiveness of using nutritional supplement mixtures consisting of arginine, glutamine, and beta-hydroxy-beta-methylbutyrate (HMB) to speed up wound healing in DFUs.

The proposed basis for including those three substances in the supplement was as follows:
  • Argine, a vasodilator, reduces bacterial load and potentiates the immunologic process, contributing to infection/inflammation reversal and expediting tissue repair.
  • Glutamine stimulates protein synthesis, supports immune function, and promotes intestinal mucosal integrity.
  • HMB, a normal anabolic muscle component, controls intracellular synthesis.

Further Reading
Patient-specific orthoses manufactured on the basis of foot shape and barefoot plantar pressure are better compared to those manufactured only on the basis of foot shape and clinical insight, according to a study published online April 23 in Diabetes Care.
The adenosine A2A receptor agonist polydeoxyribonucleotide facilitates healing of diabetic foot ulcers in patients with diabetes, according to a study published online Jan. 31 in the Journal of Clinical Endocrinology & Metabolism.
Study supports the current practice of post-surgery H. pylori eradication in patients with perforated peptic ulcers.
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Researchers report that certain classes of comorbidities increase mortality risk in patients with peptic ulcer bleeding, but the presence of any comorbidities also affects mortality risk.
Naproxen seems safer for the heart than other nonsteroidal anti-inflammatory drugs, US health officials say. And it's possible that labeling will soon reflect that finding.
Even when it’s administered in a low-dose form that resists gastric acid and prevents tablet dissolution in the stomach, aspirin therapy causes peptic ulcer and increases the risk of 30-day mortality resulting from gastrointestinal (GI) disorder progression.
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