Lidocaine metabolite N-ethylglycine (EG) relieves hyperalgesia and allodynia in animal models for chronic pain, suggests a study in Pain. The finding is an indicator that use of Glycine transporter 1 substrates might constitute a new drug target for the modulation of glycinergic inhibition in pain signaling.
Canada-based researchers examined the effectiveness of opioids for the long-term management of chronic neuropathic pain and found less than encouraging results, according to a study in The Journal of Pain.
Research has established that various parts of the trigeminal system are responsible for peripheral symptoms of migraine. Treatment with corticosteroids reduces the symptoms of migraine, but the treatment is associated with long-term side effects.
Study results show that opioid overdoses appear to frequently occur in patients who are not chronic users with high prescribed doses of opioids, in contrast to the patient groups targeted by current opioid prescribing guidelines.
Some studies have shown the benefit of a blunt, Whitacre-type needle in reducing the incidence of intravascular injection during TFESI, but other studies showed that a short-bevel needle did not reduce the incidence of intravascular injection in lumbar TFESI compared to long-bevel, Quincke-type needles.
Data concerning general outcomes and indicating performance of general pain clinics remain sparse, according to a study in the Journal of Pain and Research. The United Kingdom study suggests that this lack of standardized measurements negatively impacts the ability to judge the overall effectiveness of pain clinics, both in the UK and in other parts of the world.