May 17th 2024
The smartphone app demonstrated higher accuracy, sensitivity, and specificity in patients with severe anemia than those with moderate anemia.
Retrospective data suggest the off-label use of IVIg could be helpful in the management of severe autoimmune hemolytic anemia.
May 16th 2024
Liposomal iron achieves a partial correction of transferrin saturation, with no significant effect on iron storage and hemoglobin, in patients with NDD-CKD.
May 15th 2024
Automated anemia detection from fundus images may benefit patients undergoing routine retinal imaging.
Announced on May 15, 2024, the IND application supports a phase 1/2 study of CID among adults with chronic ITP.
Age, Genetics Help Predict Proliferative Sickle Cell Retinopathy
Age and sickle cell disease genotype predicted individuals with sickle cell retinopathy at risk for proliferative disease.
Anti-VEGF Improves Outcomes in Proliferative Sickle Cell Retinopathy
Within one month of treatment, anti-VEGF therapy improves anatomic and visual outcomes among eyes with stage 3 and 4 proliferative sickle cell retinopathy.
FDA Updates ALTUVIIIO Label with Full Pediatric Data in Hemophilia A
Announced by Sanofi on May 10, 2024, the updated FDA label is based on full results from the pivotal phase 3 XTEND-Kids study.
Hydroxyurea Dose Escalation Effective for Children with Sickle Cell Anemia
Extended follow-up of a phase 1/2 trial finds hydroxyurea dose optimization significantly improves clinical responses in children in sub-Saharan Africa with sickle cell.
Hematology Month in Review: April 2024
Our April month in review for hematology breaks down the latest updates to the pipeline, mortality risk in people with sickle cell disease, and our newest multimedia offerings.
Recombinant ADAMTS13 Prophylaxis Effective Approach for Congenital TTP
An interim analysis of a phase 3 trial displays the effectiveness of prophylaxis with recombinant ADAMTS13, achieving approximately 100% of normal ADAMTS13 levels.
SGLT2is, GLP-1s Display Reno-Protective Benefit in Sickle Cell Disease
Preliminary findings demonstrate an improvement in eGFR slope in nearly all patients with SCD after treatment with SGLT-2 inhibitors and GLP-1 receptor agonists.
Tricuspid Regurgitation Velocity Linked to Cerebrovascular, Kidney Disease in SCD
A higher TRV was significantly associated with cerebrovascular disease and persistent albuminuria in children with SCD across two large cohorts.
Rilzabrutinib Achieves Phase 3 Primary Endpoint in Immune Thrombocytopenia
Rilzabrutinib led to a durable platelet response in adult patients with persistent or chronic immune thrombocytopenia in the LUNA 3 study.
Patients with SCD Face Early Death Despite Improved Survival Rates
A recent multi-center study identified risk factors linked to premature mortality in sickle cell disease, including male gender and hematologic and biochemical parameters.
Presence of Anemia Negatively Impacts Long-Term Prognosis in HFmrEF
Anemia and iron deficiency are prevalent in heart failure with mildly reduced ejection fraction and may worsen mortality and rehospitalization outcomes.
Intravenous Iron Boosts Hemoglobin Levels in Children with Anemia, IBD
Treatment with intravenous iron therapy proves more efficacious than oral or no iron therapy in improving hemoglobin in pediatric patients admitted with IBD and IDA.
Frequent Hospitalized VOCs Worsens Mortality Risk in Sickle Cell Disease
In a nationwide study of an adult SCD population, the risk of mortality increased with the number of HVOCs in the year before death.
Current Diagnostics May Misclassify Suspected Heparin-Induced Thrombocytopenia
When the current recommended diagnostic algorithm was used in clinical practice, antibody testing was required in half of patients with suspected HIT.
Alternate-Day Iron May Be More Effective for Patients with Anemia, Diabetes
Oral iron supplements did not significantly differ in increasing hemoglobin and ferritin levels, but the every-other-day oral iron proved more effective than daily use.
Clinical Quiz: Gastrointestinal Evaluation of Iron Deficiency Anemia
This clinical quiz will test your knowledge of iron deficiency anemia, focused on the gastrointestinal evaluation of anemia based on recommendations from the AGA's 2020 guidelines.
Hematology Month in Review: March 2024
Our March 2024 month-in-review in hematology features updates to the anemia pipeline, the latest research in sickle cell disease, and the role of SGLT2 inhibition on hematologic outcomes.
Bitopertin Meets Primary Phase 2 Endpoint in Erythropoietic Protoporphyria
Topline results from AURORA indicate that while bitopertin significantly reduced PPIX levels, improvements in light tolerance were not statistically significant.
Intravenous Iron Increases Hemoglobin in Heart Failure Treated with SGLT2 Inhibition
Iron-deficient patients on an SGLT2 inhibitor at baseline experienced greater increases in hemoglobin levels with ferric derisomaltose compared with those not taking one.
Research Gaps Limit Role of Intravenous Hydration for Sickle Cell Crises
A systematic review highlights the available evidence on the use of intravenous fluid in sickle cell vaso-occlusive crises and reported adverse outcomes.
FDA Approves Vadadustat (Vafseo) Tablets for Anemia Due to CKD in Adult Patients on Dialysis
Vadadustat tablets are now approved for the treatment of anemia due to CKD in adults who have been receiving dialysis for ≥ 3 months.
Allogenic HSCT May Improve Sickle Cell Disease-Related Organ Dysfunction
A new analysis summarized evidence on the effects of allogeneic HSCT on SCD-related organ dysfunction in pediatric and adult patients with SCD.
Vadadustat Response Influenced by Patient Background in Anemia from CKD
A posthoc analysis of two phase 3 trials identified multiple independent factors associated with better response to vadadustat in patients with anemia.
Hemoglobin Levels Predict Renal Outcomes in Diabetic Kidney Disease
A study in China identified a negative and non-linear relationship between hemoglobin levels and a renal composite end point in patients with DKD.
Presence of CKD in Sickle Cell Disease Worsens In-Hospital Outcomes
Chronic kidney disease was linked to increased mortality, higher costs, and the need for mechanical ventilation among hospitalized patients with sickle cell disease.
RET-He Levels Detect Iron Deficiency in Acute Decompensated Heart Failure
Measurement of reticulocyte hemoglobin equivalent is cost-effective and could be a useful marker of iron deficiency in acute decompensated heart failure.
Substance Use Disorder of Nitrous Oxide Uncommon in Sickle Cell Disease
Results from the PHEDRE study show nitrous oxide in a gas mixture for pain was not problematic for most patients with sickle cell disease in France.
Iron Deficiency Linked to Poor Outcomes in Kidney Transplant Recipients
Iron deficiency, independent of anemia, may be a potentially modifiable target to improve patient-reported outcomes after kidney transplantation.
Anemia Exhibits Limited Association with Early Childhood Development
A cross-sectional analysis of nine low- and middle-income countries revealed few statistically significant associations between anemia and early childhood development.
Iptacopan Promotes Anemia Resolution in Paroxysmal Nocturnal Hemoglobinuria
Iptacopan monotherapy improved hematologic outcomes in both anti-C5–treated patients with persistent anemia and those not treated with complement inhibitors across two phase 3 trials.