The most successful opioid treatment programs and the most successful patients in those programs use evidence-based dosing of methadone. Many studies over the last 40 years show patients do better on adequate doses of methadone. They have better outcomes when they're on enough methadone to block physical withdrawal signs and symptoms than when they're on insufficient doses.
Studies show good efficacy and tolerability for this novel medication in the treatment of low back pain. With an estimated lifetime prevalence of 70-85%, low back pain is one of the most common causes of chronic pain in the US. However, despite the widespread prevalence of this painful condition, effective treatment remains elusive for many patients, causing a great deal of frustration not only for them but also for their treating clinicians.