The HCPLive Rheumatology condition center page is a comprehensive resource for clinical news and insights on rheumatologic disease. This page consists of interviews, articles, podcasts, and videos on the research, treatment and development of therapies for arthritis, gout, nr-AxSpA, and more.
January 31st 2023
"All forms of arthritis can make life difficult for people because of the pain, swelling, or stiffness in a joint or joints, and because of difficulties in getting about," investigators explained.
Targeting the MK2 Pathway Reduces Tachyphylaxis Related to Rheumatoid Arthritis Therapy
January 24th 2023P38 mitogen-activated protein kinase (p38 MAPK) inhibitors have been a focal point for inflammatory diseases but the lack of efficacy in treating rheumatoid arthritis led to examination of the MK2 pathway.
Low- vs High-Dose Exercise Programs Yielded Similar Benefits in Patients with Knee Osteoarthritis
The multicenter superiority trial evaluated patients with diagnosed knee osteoarthritis and a history of pain and decreased knee function using patient-tailored exercise programs.
Studies Focused on Benefits of Acupuncture, Electroacupuncture Increasing in Number in Fibromyalgia
The findings visualized the increased amount of research regarding acupuncture for fibromyalgia treatment, which may eventually boost efficacy, reduce cost, and promte future development in the field.
Vitamin D Deficiency Common Among Patients with Systemic Lupus Erythematosus
The 2-phase study analyzed the association of plasma vitamin D levels with clinical phenotype, serology, and disease variables in a large cohort of patients with systemic lupus erythematosus living in India.
Yoga, Cognitive Behavioral Therapy Improved Patient-Reported Outcomes in Fibromyalgia, IBS
Improved patient-reported outcomes were observed in patients who used mind-body interventions, such as cognitive behavioral therapy and yoga, and were effective for managing IBS and fibromyalgia.
Increased Risk of Hospitalization, Death Observed in Patients with Gout and COVID-19
Understanding the risk factors, such as a gout diagnosis and long-term glucocorticoid use, can help inform patients and clinicians regarding the continued management of patients with rheumatic disease during the COVID-19 pandemic.
Q&A: HLA-B27 Influence on Patients with Peripheral Spondyloarthritis Phenotype
January 16th 2023In this Q&A, Mireia Moreno, MD, discussed the findings of a study that evaluated the influence of HLA-B27 in the phenotypical expression of peripheral spondyloarthritis (pSpA), including psoriatic arthritis, which is the most well-defined pSpA.
Pegloticase and Methotrexate Co-Therapy Improved Urate Burden, Patient-Reported Outcomes in Gout
Serum urate rapidly declined after initiation of pegloticase and methotrexate therapy and was maintained well below ≥ 6 mg/dL, an indicator of uncontrolled gout, throughout the study.
Long-Term Cumulative Joint Inflammation Linked to Joint Damage Progression in Rheumatoid Arthritis
In the post-hoc analysis, an association between cumulative local joint swelling and progression of radiographic damage in the same joint was observed in patients with rheumatoid arthritis.
Adverse Reactions, Disease Activity Cited as Disease-Dependent Factors for Biosimilar Refusal
Disease-dependent factors, such as a history of adverse reactions to bio-originators and disease activity, influenced patients' acceptance of switching from a biologic to a biosimilar.
Distress Negatively Impacts Functionality of Patients with Fibromyalgia Experiencing Pain
The cross-sectional study evaluated the relationship between the mediating variable, distress, and pain and functionality in patients with fibromyalgia after controlling for age, gender, and income.
COVID-19 Pandemic Worsens Mental Health in Women with Fibromyalgia
“Although the evolution of COVID-19 is favorable worldwide, multiple variables related to psychological health and the response to stressors seem to have triggered symptomatologic responses in fibromyalgia patients,” investigators stated.
Early Achievement of Minimal Disease Activity Linked to Better Outcomes in Psoriatic Arthritis
Patients with psoriatic arthritis who achieve minimal disease activity during the first year of diagnosis are shown to experience better health-related quality of life, improved mental wellbeing, and reduced fatigue.
TNFi Treatment did not Increase Incidence of Hematological Malignancies in Psoriatic Arthritis
Although the incidence rates were similar among those treated with TNFi and biologics-naïve patients, patients with psoriatic arthritis had a 35% increased risk when compared with the general population.